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Imipramine Action Pathway (New)
smpdb.ca/view/SMP0126359Drug actionImipramine binds to the sodium-dependent serotonin transporter and to the sodium-dependent norepinephrine transporter reducing the reuptake of norepinephrine and serotonin by presynaptic neurons. … , and hallucinations.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Sodium-dependent serotonin transporter, Sodium-dependent noradrenaline transporterTrimipramine Action Pathway
smpdb.ca/view/SMP0126348Drug actionBy binding to the sodium-dependent serotonin transporter and the sodium-dependent noradrenaline transporter, trimipramine fulfill its functions. … It is very similar to imipramine but it has more antihistaminic and sedative properties. Trimipramine acts by decreasing the reuptake of norepinephrine and serotonin (5-HT) in the neurons.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Sodium-dependent serotonin transporter, Sodium-dependent noradrenaline transporterNortriptyline Action Pathway
smpdb.ca/view/SMP0126345Drug actionIt is possible by its binding to the sodium-dependent noradrenaline transporter and to the sodium-dependent serotonin transporter. … This drug is also used off-label and it includes the treatment of chronic pain, myofascial pain, neuralgia, and irritable bowel syndrome.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Sodium-dependent serotonin transporter, Sodium-dependent noradrenaline transporterDesipramine Action Pathway (New)
smpdb.ca/view/SMP0126352Drug actionIt binds to the sodium-dependent noradrenaline transporter and to the sodium-dependent serotonin transporter of the presynaptic neurons. … It can also be used to manage chronic neuropathic pain, as a second-line agent for the management of anxiety disorders, and as a second or third-line agent in ADHD management.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Sodium-dependent serotonin transporter, Sodium-dependent noradrenaline transporterDoxepin Norepinephrine Reuptake Inhibitor Action Pathway (New)
smpdb.ca/view/SMP0126355Drug actionDoxepin binds to the sodium-dependent noradrenaline transporter and to the sodium-dependent serotonin transporter. … Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is used for the treatment of depression, anxiety, manic-depressive disorder, and insomnia.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Tryptophan · Sapropterin · Norepinephrine +7 moreEnzymes: Sodium-dependent serotonin transporter, Sodium-dependent noradrenaline transporterSafinamide Action Pathway
smpdb.ca/view/SMP0126696Drug actionSafinamide has multiple mechanisms of action and a very high therapeutic index, it binds only the B isoform of MAO but it also inhibits sodium and calcium channels and the glutamate release channels. … The first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine.
Enzymes: Sodium-dependent dopamine transporterClomipramine Action Pathway (New)
smpdb.ca/view/SMP0126354Drug actionIt blocks both sodium-dependent serotonin and sodium-dependent norepinephrine transporters from removing serotonin and norepinephrine respectively from the synaptic clefts in the brain. … , and Tourette’s disorder.
Enzymes: Sodium-dependent serotonin transporter, Sodium-dependent noradrenaline transporterMethamphetamine Norepinephrine Reuptake Inhibitor Action Pathway
smpdb.ca/view/SMP0126618Drug actionMethamphetamine's mechanisms of action in the norepinephrine pathway is less studied, but it is known that methamphetamine is a negative modulator of sodium-dependent norepinephrine transporters like it … These cascades help regulate memory and attention.
Drugs: Pyridoxal phosphate · Ascorbic acid · Tyrosine · Norepinephrine · Dopamine · Levodopa +4 moreEnzymes: Sodium-dependent noradrenaline transporterPargyline Action Pathway
smpdb.ca/view/SMP0126708Drug actionThe first one is found in cells located in the periphery and breakdown serotonin, norepinephrine, epinephrine, dopamine, and tyramine. … The second one, the B isoform, breakdowns phenylethylamine, norepinephrine, epinephrine, dopamine, and tyramine. This isoform is found in the extracellular tissues and mainly in the brain.
Enzymes: Sodium-dependent noradrenaline transporterPhentermine Norepinephrine Reuptake transporter Satiety Action Pathway
smpdb.ca/view/SMP0126723Drug actionPhentermine inhibits the sodium-dependent noradrenaline transporter, the sodium-dependent serotonin transporter, and the sodium-dependent dopamine transporter. … This drug is administered as an oral capsule.
Enzymes: Sodium-dependent noradrenaline transporter