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Displaying results 61 - 70 of 225 in total
  1. Target

    Protein-L-isoaspartate O-methyltransferase

    go.drugbank.com/bio_entities/BE0002532
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. … It plays a role in the repair and/or degradation of damaged proteins.

    Polypeptides: Protein-L-isoaspartate O-methyltransferaseFunction: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
  2. Target

    Protein-S-isoprenylcysteine O-methyltransferase

    go.drugbank.com/bio_entities/BE0011941
    EnzymeHumans

    Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues

    Polypeptides: Protein-S-isoprenylcysteine O-methyltransferaseFunction: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
  3. Target

    Protein-serine O-palmitoleoyltransferase porcupine

    go.drugbank.com/bio_entities/BE0019221
    TargetHumans

    Protein-serine O-palmitoleoyltransferase that acts as a key regulator of the Wnt signaling pathway by mediating the attachment of palmitoleate, a 16-carbon monounsaturated fatty acid (C16:1(9Z)), to Wnt

    Polypeptides: Protein-serine O-palmitoleoyltransferase porcupine
  4. Target

    Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing

    go.drugbank.com/bio_entities/BE0004305
    TargetGeobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)

    Polypeptides: Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing
  5. Target

    Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

    go.drugbank.com/bio_entities/BE0009519
    TargetHumans

    May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380)

    Polypeptides: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
  6. Target

    Signal transducer and activator of transcription 1-alpha/beta

    go.drugbank.com/bio_entities/BE0010099
    TargetHumans

    and STAT2. … Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors (PubMed:12764129, PubMed:12855578,

    Polypeptides: Signal transducer and activator of transcription 1-alpha/beta
  7. Target

    Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

    go.drugbank.com/bio_entities/BE0003558
    TargetHumans

    Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148) … Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539).

    Polypeptides: Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11ASynonyms: cAMP and cGMP phosphodiesterase 11A
  8. Target

    Ankyrin repeat and protein kinase domain-containing protein 1

    go.drugbank.com/bio_entities/BE0009411
    TargetHumans

    Polypeptides: Ankyrin repeat and protein kinase domain-containing protein 1
  9. Target

    cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

    go.drugbank.com/bio_entities/BE0000631
    TargetHumans

    May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447) … Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447).

    Polypeptides: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
  10. Target

    2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2

    go.drugbank.com/bio_entities/BE0002203
    TargetHumans

    Polypeptides: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2