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Displaying results 61 - 70 of 186 in total
  1. Target

    TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

    go.drugbank.com/bio_entities/BE0005824
    TargetHumans

    Key adapter protein that plays an essential role in JNK and NF-kappa-B activation and proinflammatory cytokines production in response to stimulation with TLRs and cytokines (PubMed:22307082, PubMed:24403530 … Similarly, associates with MAPK14 and triggers its autophosphorylation and subsequent activation (PubMed:11847341, PubMed:29229647).

    Polypeptides: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
  2. Target

    General transcription and DNA repair factor IIH helicase/translocase subunit XPB

    go.drugbank.com/bio_entities/BE0012820
    TargetHumans

    The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape (PubMed:10024882). … In transcription pre-initiation complexes induces and propagates a DNA twist to open DNA (PubMed:27193682, PubMed:33902107).

    Polypeptides: General transcription and DNA repair factor IIH helicase/translocase subunit XPB
  3. Target

    Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

    go.drugbank.com/bio_entities/BE0005530
    TargetHumans

    Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation (PubMed:22279049). … In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement (PubMed:22279049).

    Polypeptides: Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENSynonyms: Phosphatase and tensin homolog
  4. Target

    High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

    go.drugbank.com/bio_entities/BE0003717
    TargetHumans

    Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299) … May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167).

    Polypeptides: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
  5. Target

    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

    go.drugbank.com/bio_entities/BE0018277
    TargetHumans

    Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). … Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity)

    Polypeptides: Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1Synonyms: Leucine-rich repeat and immunoglobulin domain-containing protein 1
  6. Target

    Lead

    go.drugbank.com/bio_entities/BE0004808
    TargetHumans

  7. Target

    Aldehyde oxidoreductase

    go.drugbank.com/bio_entities/BE0001458
    TargetDesulfovibrio gigas

    Synonyms: Molybdenum iron sulfur proteinFunction: 2 iron, 2 sulfur cluster binding
  8. Target

    2-oxo-1,2-dihydroquinoline 8-monooxygenase, oxygenase component

    go.drugbank.com/bio_entities/BE0003357
    TargetPseudomonas putida

    Synonyms: Rieske (2Fe-2S) iron-sulfur domain containing proteinFunction: 2 iron, 2 sulfur cluster binding
  9. Target

    Cytochrome b-c1 complex subunit Rieske, mitochondrial

    go.drugbank.com/bio_entities/BE0003858
    TargetHumans

    The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. … and the ATP synthase.

    Synonyms: Rieske iron-sulfur protein, Ubiquinol-cytochrome c reductase iron-sulfur subunitFunction: 2 iron, 2 sulfur cluster binding
  10. Target

    Succinate dehydrogenase

    go.drugbank.com/bio_entities/BE0010253
    EnzymeTargetHumans

    Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed … Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to

    Polypeptides: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialSynonyms: Iron-sulfur subunit of complex II, Malate dehydrogenase [quinone] iron-sulfur subunit