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Polycystin-2-like protein 1
go.drugbank.com/bio_entities/BE0008712TransporterHumansThe homomeric and heteromeric channels formed by PKD1L2 and PKD1L3 are activated by low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus (PubMed
Polypeptides: Polycystin-2-like protein 1Synonyms: Polycystin-2 homolog, Polycystic kidney disease 2-like 1 proteinCyclin-dependent kinase-like 2
go.drugbank.com/bio_entities/BE0009423TargetHumansPolypeptides: Cyclin-dependent kinase-like 2eIF-2-alpha kinase GCN2
go.drugbank.com/bio_entities/BE0009435TargetHumansMetabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability (PubMed:25329545 … EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha into a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, and thus to
Polypeptides: eIF-2-alpha kinase GCN2Synonyms: Eukaryotic translation initiation factor 2-alpha kinase 4Inward rectifier potassium channel 2
go.drugbank.com/bio_entities/BE0009710TargetHumansInward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:36149965, PubMed:7590287, PubMed:9490857). Their voltage dependence is regulated by the co...
Polypeptides: Inward rectifier potassium channel 2Synonyms: Potassium channel, inwardly rectifying subfamily J member 2Free fatty acid receptor 2
go.drugbank.com/bio_entities/BE0010131TargetHumansG protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omni...
Polypeptides: Free fatty acid receptor 2Bcl-2-related protein A1
go.drugbank.com/bio_entities/BE0010682TargetHumansRetards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvat...
Polypeptides: Bcl-2-related protein A1Synonyms: Bcl-2-like protein 5, Bcl2-L-5Leukocyte cell-derived chemotaxin-2
go.drugbank.com/bio_entities/BE0011408TargetHumansHas a neutrophil chemotactic activity. Also a positive regulator of chondrocyte proliferation (PubMed:9524238). Does not show metalloendopeptidase activity (PubMed:27334921)
Polypeptides: Leukocyte cell-derived chemotaxin-2Synonyms: LECT-2Vasoactive intestinal polypeptide receptor 2
go.drugbank.com/bio_entities/BE0013151TargetHumansG protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:7811244, PubMed:35477937, PubMed:8933357). Binds VIP and both PA...
Polypeptides: Vasoactive intestinal polypeptide receptor 2Synonyms: VIP-R-2Inward rectifier potassium channel 2
go.drugbank.com/bio_entities/BE0027705TargetRatInward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as externa...
Polypeptides: Inward rectifier potassium channel 2Synonyms: Potassium channel, inwardly rectifying subfamily J member 2Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
go.drugbank.com/bio_entities/BE0003565TargetHumansCalcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compa...
Polypeptides: Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AFunction: 3',5'-cyclic-AMP phosphodiesterase activity