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Displaying results 731 - 740 of 10000 in total
  1. Indication

    Adrenal Cushing Syndrome

    go.drugbank.com/conditions/DBCOND0148294
    Drugs: Mitotane
    Synonyms: Cushing s Syndrome
  2. Indication

    Adult Onset Still's Disease

    go.drugbank.com/conditions/DBCOND0136303
    Drugs: Canakinumab
    Synonyms: Adult-Onset Still´s Disease
  3. Drug

    Tranexamic acid

    go.drugbank.com/drugs/DB00302
    ApprovedInvestigational

    Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. … It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent.

    Synonyms: trans-4-aminomethylcyclohexane-1-carboxylic acid, trans-4-(Aminomethyl)cyclohexanecarboxylic acidInternational brands: Cyclo-F
  4. Drug

    Samidorphan

    go.drugbank.com/drugs/DB12543
    ApprovedInvestigational

    [A235638, A235643] Samidorphan is a novel opioid antagonist structurally related to [naltrexone], with a higher affinity for opioid receptors, more potent μ-opioid receptor antagonism, higher oral bioavailability … [A235638, A235643] Samidorphan was first approved as a variety of fixed-dose combination tablets with [olanzapine] by the FDA on May 28, 2021, and is currently marketed under the trademark LYBALVI™

    Salts: Samidorphan L-malateCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A Substrates
  5. Target

    Protein S100-B

    go.drugbank.com/bio_entities/BE0001177
    TargetHumans

    Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:20950652, PubMed:6487634). Weakly binds calcium but binds zinc very tightly-di...

    Synonyms: S-100 protein beta chain, S-100 protein subunit beta
  6. Drug

    Bortezomib

    go.drugbank.com/drugs/DB00188
    ApprovedInvestigational

    Bortezomib is a dipeptide boronic acid derivative and proteasome inhibitor used to treat multiple myeloma and mantle cell lymphoma. … [A204083] The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest and

    Synonyms: [(1R)-3-methyl-1-({(2S)-3-phenyl-2-[(pyrazin-2-ylcarbonyl)amino]propanoyl}amino)butyl]boronic acid, N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamideCategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index
  7. Indication

    Menière's Disease

    go.drugbank.com/conditions/DBCOND0066647
    Drugs: Betahistine · Dimenhydrinate · Diphenidol · Pyridoxine · Streptomycin · Sulpiride
    Synonyms: Meniere s Disease
  8. Target

    Protein S100-A1

    go.drugbank.com/bio_entities/BE0001090
    TargetHumans

    Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) l...

    Synonyms: S-100 protein alpha chain, S-100 protein subunit alpha
  9. Indication

    Fabry's Disease

    go.drugbank.com/conditions/DBCOND0028300
    Drugs: Agalsidase alfa · Agalsidase beta · Migalastat · Pegunigalsidase alfa
    Synonyms: Fabry´s Disease
  10. Drug

    Octasulfur

    go.drugbank.com/drugs/DB09353
    Approved

    Sulfur is a chemical element that is present in all living tissues. The most commonly used form of pharmaceutical sulfur is Octasulfur (S8). … After calcium and phosphorus, it is the third most abundant mineral in the human body. Sulfur is also found in garlic, onions and broccoli.

    Mixtures: RED BETTER SPOT CORRECTOR non-drying acne balm, Se 10-5 SsProducts: S. Wongs Acne Treatment Sulphur, DermaWash S2