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Conivaptan
go.drugbank.com/drugs/DB00872ApprovedConivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin). It was approved in 2004 for hyponatremia (low blood sodium levels) caused by syndrome of inappropriate antidiuretic hormone (SIADH). Conivaptan inhibits both is...
Synonyms: 4'-((4,5-dihydro-2-methylimidazo(4,5-d)(1)benzazepin-6(1H)-yl)carbonyl)-2-biphenylcarboxanilideCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesRimexolone
go.drugbank.com/drugs/DB00896ApprovedWithdrawnRimexolone is a 1% eye drop solution is a glucocorticoid steroid. It is used to treat inflammation in the eye. It is marketed as Vexol.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersTinidazole
go.drugbank.com/drugs/DB00911ApprovedInvestigationalA nitroimidazole antitrichomonal agent effective against Trichomonas vaginalis, Entamoeba histolytica, and Giardia lamblia infections.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesTelithromycin
go.drugbank.com/drugs/DB00976ApprovedTelithromycin, a semi-synthetic erythromycin derivative, belongs to a new chemical class of antibiotics called ketolides. Ketolides have been recently added to the macrolide-lincosamide-streptogramin class of antibiotics. Similar to the ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsLomefloxacin
go.drugbank.com/drugs/DB00978ApprovedLomefloxacin is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections (UTIs). Additionally, it has been employed for the prophylaxis of UTIs prior to surgery as well.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsPerhexiline
go.drugbank.com/drugs/DB01074ApprovedPerhexiline is a coronary vasodilator used especially for angina of effort. It may cause neuropathy and hepatitis.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesProguanil
go.drugbank.com/drugs/DB01131ApprovedProguanil is a prophylactic antimalarial drug, which works by stopping the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofo...
Synonyms: 1-(p-Chlorophenyl)-5-isopropylbiguanideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesEthambutol
go.drugbank.com/drugs/DB00330ApprovedInvestigationalEthambutol is a bacteriostatic agent indicated alongside medications such as isoniazid, rifampin, and pyrazinamide in the treatment of pulmonary tuberculosis. Ethambutol was first described in the literature in 1961. It was developed out...
Synonyms: (+)-2,2'-(ethylenediimino)di-1-butanolCategories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 InhibitorsDydrogesterone
go.drugbank.com/drugs/DB00378ApprovedInvestigationalWithdrawnA synthetic progestational hormone with no androgenic or estrogenic properties. Unlike many other progestational compounds, dydrogesterone produces no increase in temperature and does not inhibit ovulation.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesNisoldipine
go.drugbank.com/drugs/DB00401ApprovedNisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in s...
International brands: Di Yi XinCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates