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Interleukin-17 receptor D
go.drugbank.com/bio_entities/BE0017358TargetHumansFeedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation (PubMed:12807873, PubMed:12958313). Regulates the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK wi...
Polypeptides: Interleukin-17 receptor DSynonyms: IL-17 receptor D, Interleukin-17 receptor-like proteinLysophosphatidic acid receptor 1
go.drugbank.com/bio_entities/BE0017535TargetHumansReceptor for lysophosphatidic acid (LPA) (PubMed:19306925, PubMed:25025571, PubMed:26091040, PubMed:9070858). … Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins.
Polypeptides: Lysophosphatidic acid receptor 1Synonyms: LPA receptor 1, Lysophosphatidic acid receptor Edg-2Interleukin-17 receptor A
go.drugbank.com/bio_entities/BE0018249TargetHumansReceptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). … Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848)
Polypeptides: Interleukin-17 receptor ASynonyms: IL-17 receptor AInterleukin-17 receptor B
go.drugbank.com/bio_entities/BE0020027TargetHumansReceptor for the pro-inflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells
Polypeptides: Interleukin-17 receptor BSynonyms: IL-17 receptor B, IL-17B receptorInsulin receptor substrate 2
go.drugbank.com/bio_entities/BE0021286TargetHumansSignaling adapter protein that participates in the signal transduction from two prominent receptor tyrosine kinases, insulin receptor/INSR and insulin-like growth factor I receptor/IGF1R (PubMed:25879670 … Upon phosphorylation by the insulin receptor, functions as a signaling scaffold that propagates insulin action through binding to SH2 domain-containing proteins including the p85 regulatory subunit of
Polypeptides: Insulin receptor substrate 2Insulin glargine
go.drugbank.com/drugs/DB00047ApprovedInvestigationalThe resulting protein is soluble at pH 4 and forms microprecipitates at physiological pH 7.4 allowing for the slow release of small amounts of insulin glargine, giving the drug a long duration of action
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 Enzyme InducersDosulepin
go.drugbank.com/drugs/DB09167ApprovedInvestigationalDosulepin (INN, BAN) formerly known as dothiepin (USAN), is a tricyclic antidepressant with anxiolytic properties that is used in several European and South Asian countries, as well as Australia, South
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2C9 InhibitorsDaprodustat
go.drugbank.com/drugs/DB11682ApprovedInvestigationalDaprodustat is a small-molecule hypoxia-inducible factor (HIF) prolyl hydroxylase (PHD) inhibitor that was developed by GSK. Patients with CKD cannot induce erythropoietin (EPO) production in response to hypoxia or anemia. As a potent in...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsTelmisartan
go.drugbank.com/drugs/DB00966ApprovedInvestigational[A1489,A1490] Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.[A1492] … Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 Enzyme InhibitorsSonrotoclax
go.drugbank.com/drugs/DB18753ApprovedInvestigational[L56193,A275521] Sonrotoclax was rationally designed as a BH3 mimetic with a shallow and broad interaction with the P2 pocket of BCL-2, achieved through a novel 7-azaspiro[3.5]nonane linker; this binding
Categories: P-glycoprotein substrates, Cytochrome P-450 Substrates