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Displaying results 771 - 780 of 10000 in total
  1. Target

    Adrenocorticotropic hormone receptor

    go.drugbank.com/bio_entities/BE0000848
    TargetHumans

    G protein-coupled receptor for corticotropin/ACTH, primarily expressed in adrenal cortex where it plays a key role in the regulation of adrenocortical function (PubMed:1325670, PubMed:17596328, PubMed:

    Polypeptides: Adrenocorticotropic hormone receptorSynonyms: ACTH receptor, Melanocortin receptor 2
  2. Target

    Adenosine receptor A2a

    go.drugbank.com/bio_entities/BE0000924
    TargetHumans

    Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity)

    Polypeptides: Adenosine receptor A2a
  3. Target

    Substance-K receptor

    go.drugbank.com/bio_entities/BE0002222
    TargetHumans

    Substance K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:7957923, PubMed:35882833). … This is a receptor for the tachykinin neuropeptide substance K (neurokinin A) (PubMed:1659297, PubMed:1848773).

    Polypeptides: Substance-K receptorSynonyms: NK-2 receptor, Neurokinin A receptor
  4. Target

    KiSS-1 receptor

    go.drugbank.com/bio_entities/BE0003468
    TargetHumans

    Receptor for kisspeptins (kisspeptin-10, kisspeptin-13, kisspeptin-14 and metastin/kisspeptin-54) (PubMed:11457843, PubMed:11527393, PubMed:15020672, PubMed:15596153). … In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed

    Polypeptides: KiSS-1 receptorSynonyms: Metastin receptor, Kisspeptins receptor
  5. Target

    Aryl hydrocarbon receptor

    go.drugbank.com/bio_entities/BE0003721
    TargetHumans

    Ligand-activated transcription factor that enables cells to adapt to changing conditions by sensing compounds from the environment, diet, microbiome and cellular metabolism, and which plays important roles in development, immunity and ca...

    Polypeptides: Aryl hydrocarbon receptorSynonyms: Ah receptor
  6. Target

    Colicin I receptor

    go.drugbank.com/bio_entities/BE0004172
    TargetTransporterEscherichia coli (strain K12)

    Outer membrane receptor for colicins IA and IB.

    Polypeptides: Colicin I receptor
  7. Target

    GABA(A) Receptor

    go.drugbank.com/bio_entities/BE0004797
    TargetHumans

    GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity). … GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity)

    Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit alpha-2Synonyms: GABA(A) receptor subunit alpha-1, GABA(A) receptor subunit alpha-2
  8. Target

    Glutamate (NMDA) receptor

    go.drugbank.com/bio_entities/BE0004852
    TargetHumans

    Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits. … Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits (PubMed:38598639).

    Polypeptides: Glutamate receptor ionotropic, NMDA 1, Glutamate receptor ionotropic, NMDA 2ASynonyms: Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1
  9. Target

    Alpha adrenergic receptor

    go.drugbank.com/bio_entities/BE0004888
    TargetHumans

    Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenge...

    Polypeptides: Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptorSynonyms: Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c
  10. Target

    Ryanodine receptor 2

    go.drugbank.com/bio_entities/BE0005295
    TargetTransporterHumans

    Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead ...

    Polypeptides: Ryanodine receptor 2Synonyms: Type 2 ryanodine receptor, Cardiac muscle ryanodine receptor