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Displaying results 771 - 780 of 10000 in total
  1. Target

    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase

    go.drugbank.com/bio_entities/BE0001402
    TargetVACV

    Displays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the...

    Synonyms: PAP-S
  2. Target

    Uroporphyrinogen-III C-methyltransferase

    go.drugbank.com/bio_entities/BE0002528
    TargetPseudomonas denitrificans

    Catalyzes the two successive C-2 and C-7 methylation reactions involved in the conversion of uroporphyrinogen III to precorrin-2 via the intermediate formation of precorrin-1. It is a step in the biosynthesis of both cobalamin (vitamin B...

    Synonyms: S-adenosyl-L-methionine:uroporphyrinogen III methyltransferase
  3. Target

    Lactoylglutathione lyase

    go.drugbank.com/bio_entities/BE0000962
    TargetEnzymeHumans

    Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:20454679, PubMed:23122816, PubMed:9705294).

    Synonyms: S-D-lactoylglutathione methylglyoxal lyase
  4. Target

    Hydroxymycolate synthase MmaA4

    go.drugbank.com/bio_entities/BE0003863
    TargetMycobacterium tuberculosis

    Probably transfers a methyl group from the S-adenosylmethionine (SAM) cofactor and, subsequently or simultaneously, a water molecule onto the double bound of ethylene substrates, leading to the formation

    Synonyms: S-adenosylmethionine-dependent methyltransferase
  5. Target

    Cyanocobalamin reductase / alkylcobalamin dealkylase

    go.drugbank.com/bio_entities/BE0002175
    TargetHumans

    Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate (PubMed:187795...

    Synonyms: Alkylcobalamin:glutathione S-alkyltransferase
  6. Drug

    Guaifenesin

    go.drugbank.com/drugs/DB00874
    ApprovedInvestigationalVet approved

    used as an expectorant [F4525]. … Guaifenesin possesses a storied history, having been originally formally approved by the US FDA in 1952 and continues to be one of very few - if not perhaps the only drug that is readily available and

    Mixtures: Pancold S, Colcol-SInternational brands: Sinumist-SR, Duratuss G
  7. Drug

    Netarsudil

    go.drugbank.com/drugs/DB13931
    ApprovedInvestigational

    solution) 0.02% for the indication of reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. … Acting as both a rho kinase inhibitor and a norepinephrine transport inhibitor, Netarsudil is a novel glaucoma medication in that it specifically targets the conventional trabecular pathway of aqueous

    Synonyms: (4-((1S)-1-(Aminomethyl)-2-(isoquinolin-6-ylamino)-2-oxoethyl)phenyl)methyl 2,4- dimethylbenzoate
  8. Drug

    Benzocaine

    go.drugbank.com/drugs/DB01086
    ApprovedInvestigational

    Benzocaine is an ester local anesthetic that acts by preventing transmission of impulses along nerve fibers and at nerve endings. … [A231219] It is commonly used for local anesthesia in many over the counter products.[L32454,L32459,L32464] Benzocaine was first used for local anesthesia in dentistry.[A231259]

    Synonyms: p-Carbethoxyaniline, Ethyl p-aminobenzoateMixtures: Coghlan s Sting Relief, Budpak Feminine Anti-Itch
  9. Target

    Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

    go.drugbank.com/bio_entities/BE0004448
    TargetHumans

    GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA (PubMed:15987998, PubMed:19417105, PubMed:2511002, PubMed:27863242). GS...

    Synonyms: G1 to S phase transition protein 1 homolog
  10. Drug

    Diphenhydramine

    go.drugbank.com/drugs/DB01075
    ApprovedInvestigational

    As a result, diphenhydramine is being investigated for its anxiolytic and anti-depressant properties. … Diphenhydramine - perhaps known most commonly as its brand name formulation Benadryl - is a first-generation H1 receptor antihistamine that is used extensively for the treatment of seasonal allergies,

    Synonyms: N-(2-(diphenylmethoxy)ethyl)-N,N-dimethylamine, 2-(benzhydryloxy)-N,N-dimethylethylamineInternational brands: Dormarex 2