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Metallo-beta-lactamase type 2
go.drugbank.com/bio_entities/BE0009973TargetEnzymeKlebsiella pneumoniaeConfers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin.
Polypeptides: Metallo-beta-lactamase type 2Elongation factor 1-alpha 2
go.drugbank.com/bio_entities/BE0010196TargetHumansTranslation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon...
Polypeptides: Elongation factor 1-alpha 2Synonyms: eEF1A-2, EF-1-alpha-2Insulin-like growth factor 2
go.drugbank.com/bio_entities/BE0010370TargetHumansThe insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved i...
Polypeptides: Insulin-like growth factor 2Synonyms: IGF-2Cytokine receptor-like factor 2
go.drugbank.com/bio_entities/BE0010586TargetHumansReceptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in ...
Polypeptides: Cytokine receptor-like factor 2Synonyms: Cytokine receptor-like 2C-terminal-binding protein 2
go.drugbank.com/bio_entities/BE0013651TargetHumansCorepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity)
Polypeptides: C-terminal-binding protein 2Corticotropin-releasing hormone receptor 2
go.drugbank.com/bio_entities/BE0014244TargetHumansG protein-coupled receptor for CRH, UCN, UCN2 and UCN3 stress hormones, which plays a central role in whole body adaptation to stress (PubMed:11329063, PubMed:11416224, PubMed:20966082, PubMed:22689579, PubMed:32004470, PubMed:36335102)....
Polypeptides: Corticotropin-releasing hormone receptor 2Synonyms: CRFR-2, CRF-R-22-hydroxyacylsphingosine 1-beta-galactosyltransferase
go.drugbank.com/bio_entities/BE0015078EnzymeHumansCatalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system (PubMed...
Polypeptides: 2-hydroxyacylsphingosine 1-beta-galactosyltransferaseFatty-acid amide hydrolase 2
go.drugbank.com/bio_entities/BE0015331EnzymeHumansCatalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to thei...
Polypeptides: Fatty-acid amide hydrolase 2Synonyms: Oleamide hydrolase 2, Anandamide amidohydrolase 2Sodium/myo-inositol cotransporter 2
go.drugbank.com/bio_entities/BE0017647TransporterHumansInvolved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1 (PubMed:15172003, PubMed:19032932).
Polypeptides: Sodium/myo-inositol cotransporter 2Synonyms: Solute carrier family 5 member 11, Na(+)/myo-inositol cotransporter 2Mitochondrial amidoxime reducing component 2
go.drugbank.com/bio_entities/BE0017987EnzymeHumansCatalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752). As a component of prodrug-converting system, reduc...
Polypeptides: Mitochondrial amidoxime reducing component 2Synonyms: MOSC domain-containing protein 2, Moco sulfurase C-terminal domain-containing protein 2