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Displaying results 781 - 790 of 10000 in total
  1. Target

    ATP-binding cassette sub-family C member 1

    go.drugbank.com/bio_entities/BE0000785
    TargetTransporterHumans

    Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. … Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells (PubMed:9426231).

    Synonyms: Glutathione-S-conjugate-translocating ATPase ABCC1Function: ABC-type glutathione S-conjugate transporter activity
  2. Target

    RalA-binding protein 1

    go.drugbank.com/bio_entities/BE0004770
    TransporterHumans

    Multifunctional protein that functions as a downstream effector of RALA and RALB (PubMed:7673236). As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7673236). As part of the Ral...

    Synonyms: Dinitrophenyl S-glutathione ATPaseFunction: ABC-type glutathione S-conjugate transporter activity
  3. Target

    NACHT, LRR and PYD domains-containing protein 3

    go.drugbank.com/bio_entities/BE0010347
    TargetHumans

    Sensor component of the NLRP3 inflammasome, which mediates inflammasome activation in response to defects in membrane integrity, leading to secretion of inflammatory cytokines IL1B and IL18 and pyroptosis (PubMed:16407889, PubMed:1840367...

    Polypeptides: NACHT, LRR and PYD domains-containing protein 3
  4. Target

    Cytochrome P450 2C8

    go.drugbank.com/bio_entities/BE0002887
    TargetEnzymeHumans

    A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576, PubMed:7574697). Mecha...

    Synonyms: S-mephenytoin 4-hydroxylase
  5. Target

    Excretory Secretory (ES) proteins

    go.drugbank.com/bio_entities/BE0009630
    TargetFasciola hepatica

    Synonyms: Glutathione S-transferase omega classPolypeptides: Glutathione S-transferase omega class
  6. Target

    Laminin subunit gamma-1

    go.drugbank.com/bio_entities/BE0002107
    TargetHumans

    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a su...

    Synonyms: S-LAM gamma, S-laminin subunit gamma
  7. Drug

    Guaifenesin

    go.drugbank.com/drugs/DB00874
    ApprovedInvestigationalVet approved

    used as an expectorant [F4525]. … Guaifenesin possesses a storied history, having been originally formally approved by the US FDA in 1952 and continues to be one of very few - if not perhaps the only drug that is readily available and

    Mixtures: Pancold S, Colcol-SInternational brands: Sinumist-SR, Duratuss G
  8. Target

    Kynurenine--oxoglutarate transaminase 3

    go.drugbank.com/bio_entities/BE0002162
    TargetHumans

    May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond.

    Synonyms: Cysteine-S-conjugate beta-lyase 2Function: cysteine-S-conjugate beta-lyase activity
  9. Target

    Nitric oxide synthase 1

    go.drugbank.com/bio_entities/BE0000067
    TargetEnzymeHumans

    Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR

    Synonyms: Peptidyl-cysteine S-nitrosylase NOS1
  10. Target

    4-aminobutyrate aminotransferase, mitochondrial

    go.drugbank.com/bio_entities/BE0000253
    TargetEnzymeHumans

    Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively (PubMed:10407778, PubMed:15528998). Can also convert delta-aminovalerate and beta-alanine...

    Synonyms: (S)-3-amino-2-methylpropionate transaminaseFunction: (S)-3-amino-2-methylpropionate