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Dofetilide
go.drugbank.com/drugs/DB00204ApprovedInvestigationalDofetilide is a class III antiarrhythmic agent that is approved by the Food and Drug Administration (FDA) for the maintenance of sinus rhythm in individuals prone to the formation of atrial fibrillation and flutter, and for the chemical ...
Synonyms: beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidideCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesIsradipine
go.drugbank.com/drugs/DB00270ApprovedIsradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blo...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesDisopyramide
go.drugbank.com/drugs/DB00280ApprovedInvestigationalA class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also po...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesGepotidacin
go.drugbank.com/drugs/DB12134ApprovedInvestigationalGepotidacin is a first-in-class triazaacenaphthylene antibacterial targeting bacterial DNA gyrase and topoisomerase IV. Its target is similar to that of fluoroquinolone antibacterials - e.g. ciprofloxacin - while being structurally and p...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesBrigatinib
go.drugbank.com/drugs/DB12267ApprovedInvestigationalBrigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It ...
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesPiperine
go.drugbank.com/drugs/DB12582InvestigationalBioperine has been used in trials studying the treatment of Multiple Myeloma and Deglutition Disorders.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 CYP3A InhibitorsCloprednol
go.drugbank.com/drugs/DB13843InvestigationalCloprednol is a synthetic glucocorticoid that has been investigated for use in the treatment of asthma.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersDexniguldipine
go.drugbank.com/drugs/DB14068ExperimentalCategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesDL-alpha-Tocopherol
go.drugbank.com/drugs/DB14476ApprovedInvestigationalSynonyms: DL-α-tocopherol, DL-alpha tocopherolMixtures: Escavite DHomochlorcyclizine
go.drugbank.com/drugs/DB15979InvestigationalCategories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme Inhibitors