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Displaying results 71 - 80 of 2763 in total
  1. Target

    Polyubiquitin-C

    go.drugbank.com/bio_entities/BE0004087
    TargetHumans

    Exists either covalently attached to another protein, or free (unanchored). … As a monoubiquitin, its C-terminal glycine is recognized as a C-degron by Cul2-RING (CRL2) E3 ubiquitin-protein ligase complexes (PubMed:39548056)

    Polypeptides: Polyubiquitin-CFunction: protein tag activity
  2. Target

    Cytochrome c'

    go.drugbank.com/bio_entities/BE0002563
    TargetRhodobacter capsulatus

    Cytochrome c' is the most widely occurring bacterial c-type cytochrome. Cytochromes c' are high-spin proteins and the heme has no sixth ligand. Their exact function is not known.

    Polypeptides: Cytochrome c'
  3. Target

    C-X-C chemokine receptor type 1

    go.drugbank.com/bio_entities/BE0003552
    TargetHumans

    This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698)

    Polypeptides: C-X-C chemokine receptor type 1Function: C-C chemokine binding
  4. Target

    C-X-C chemokine receptor type 2

    go.drugbank.com/bio_entities/BE0010516
    TargetHumans

    This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). Binds to IL-8 with high affinity.

    Polypeptides: C-X-C chemokine receptor type 2Function: C-C chemokine binding
  5. Target

    C-X-C motif chemokine 10

    go.drugbank.com/bio_entities/BE0000934
    TargetHumans

    Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium

    Polypeptides: C-X-C motif chemokine 10Synonyms: 10 kDa interferon gamma-induced protein
  6. Target

    C-X-C motif chemokine 6

    go.drugbank.com/bio_entities/BE0014005
    TargetHumans

    Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and ...

    Polypeptides: C-X-C motif chemokine 6Synonyms: Granulocyte chemotactic protein 2
  7. Target

    C-X-C motif chemokine 5

    go.drugbank.com/bio_entities/BE0010821
    TargetHumans

    Involved in neutrophil activation. In vitro, ENA-78(8-78) and ENA-78(9-78) show a threefold higher chemotactic activity for neutrophil granulocytes

    Polypeptides: C-X-C motif chemokine 5Synonyms: Epithelial-derived neutrophil-activating protein 78
  8. Target

    C-X-C motif chemokine 3

    go.drugbank.com/bio_entities/BE0012848
    TargetHumans

    Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold...

    Polypeptides: C-X-C motif chemokine 3Synonyms: Growth-regulated protein gamma, Macrophage inflammatory protein 2-beta
  9. Target

    C-X-C chemokine receptor type 4

    go.drugbank.com/bio_entities/BE0000919
    TargetHumans

    Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed … CXCR4 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed:17197449, PubMed:39093700). Involved in the AKT signaling cascade (PubMed:24912431).

    Polypeptides: C-X-C chemokine receptor type 4Synonyms: LPS-associated protein 3, Lipopolysaccharide-associated protein 3
  10. Target

    Apolipoprotein C-III

    go.drugbank.com/bio_entities/BE0008880
    TargetHumans

    Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806...

    Polypeptides: Apolipoprotein C-III