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Displaying results 801 - 810 of 10000 in total
  1. Drug

    Chlorthalidone

    go.drugbank.com/drugs/DB00310
    ApprovedInvestigational

    These pathways may play a role in chlorthalidone's cardiovascular risk reduction effects.[A176330] … Chlorthalidone improves blood pressure and swelling by preventing water absorption from the kidneys through inhibition of the Na+/Cl− symporter in the distal convoluted tubule cells in the kidney.

    Mixtures: ATENOLOLO CLORTALIDONE EG, ATENOLOLO CLORTALIDONE EG
  2. Target

    Copper chaperone for superoxide dismutase

    go.drugbank.com/bio_entities/BE0005815
    CarrierTargetHumans

    Delivers copper to copper zinc superoxide dismutase (SOD1)

    Polypeptides: Copper chaperone for superoxide dismutaseSynonyms: Superoxide dismutase copper chaperone
  3. Target

    Cytochrome c oxidase copper chaperone

    go.drugbank.com/bio_entities/BE0008686
    CarrierHumans

    Copper metallochaperone involved in the assembly of cytochrome c oxidase (respiratory chain complex IV, CIV) (PubMed:15229189, PubMed:19393246, PubMed:31903891, PubMed:35750769). … Binds two copper ions and delivers them to metallochaperones SCO1 and SCO2, which co-chaperone the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2), and to metallochaperone

    Polypeptides: Cytochrome c oxidase copper chaperoneFunction: copper chaperone activity
  4. Drug

    Tenofovir disoproxil

    go.drugbank.com/drugs/DB00300
    ApprovedInvestigational

    Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase … This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].

    Mixtures: Symfi Lo, Symfi LoCategories: Antivirals used in combination for the treatment of HIV infections
  5. Drug

    Citric acid

    go.drugbank.com/drugs/DB04272
    ApprovedInvestigationalNutraceuticalVet approved

    Citric acid is one of the active ingredients in Phexxi, a non-hormonal contraceptive agent that was approved by the FDA on May 2020. … A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium-chelating ability.

    Mixtures: Juans Santo Remedio PARA LA ACIDEZ, Acd-ACategories: Compounds used in a research, industrial, or household setting, Disinfectants (For Agents Used on Object)
  6. Drug

    Beclomethasone dipropionate

    go.drugbank.com/drugs/DB00394
    ApprovedInvestigational

    Beclomethasone dipropionate became first available in a pressurized metered-dose inhaler in 1972 and later in a dry powder inhaler and an aqueous nasal spray. … [L6871] It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP)[A179839] which acts on the glucocorticoid receptor to mediates its therapeutic action.

    International brands: Clenil-AMixtures: FORMODUAL N. 200/6UG, FORMODUAL N. 200/6UG
  7. Indication

    Nosocomial Pneumonia caused by Acinetobacter Baumannii-calcoaceticus Complex

    go.drugbank.com/conditions/DBCOND0159090
    Drugs: Durlobactam · Sulbactam
    Synonyms: Nosocomial Pneumonia caused by Acinetobacter Baumannii-calcoaceticus Complex
  8. Drug

    Meloxicam

    go.drugbank.com/drugs/DB00814
    ApprovedInvestigationalVet approved

    [A190189] With a longer half-life than most other NSAIDS, it is a favorable option for those who require once-daily dosing. Meloxicam is available in oral, transdermal, and intravenous formulations. … It is a preferential COX-2 inhibitor, purportedly reducing the risk of adverse gastrointestinal tract effects, however, this is a topic of controversy.[A190198,A190201]

    Products: MELOXICAM EG, MELOXICAM AL 15MG TABL
  9. Target

    Amine oxidase [copper-containing] 3

    go.drugbank.com/bio_entities/BE0001002
    TargetEnzymeHumans

    Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:19588076, PubMed:24304424, PubMed:9653080). Has a preference for the primary mo...

    Polypeptides: Amine oxidase [copper-containing] 3Synonyms: Copper amine oxidase, Amine oxidase copper-containing 3
  10. Target

    Polycomb complex protein BMI-1

    go.drugbank.com/bio_entities/BE0013109
    TargetHumans

    Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development … In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:21772249, PubMed:26151332)

    Polypeptides: Polycomb complex protein BMI-1