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Displaying results 801 - 810 of 10000 in total
  1. Target

    Methionine synthase

    go.drugbank.com/bio_entities/BE0003310
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

    Synonyms: 5-methyltetrahydrofolate S-homocysteine methyltransferase
  2. Target

    Protein S100-A2

    go.drugbank.com/bio_entities/BE0003602
    TargetHumans

    May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May a...

    Synonyms: Protein S-100L
  3. Target

    Arsenite methyltransferase

    go.drugbank.com/bio_entities/BE0005015
    TargetEnzymeHumans

    Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is redu...

    Synonyms: S-adenosyl-L-methionine:arsenic(III) methyltransferase
  4. Target

    ATP-citrate synthase

    go.drugbank.com/bio_entities/BE0009867
    TargetEnzymeHumans

    Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism

    Synonyms: ATP-citrate (pro-S-)-lyase
  5. Drug

    Zoledronic acid

    go.drugbank.com/drugs/DB00399
    ApprovedInvestigational

    Zoledronic acid, or CGP 42'446,[A203120] is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid]. … [A203111] Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone.

    Synonyms: (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid, (1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acidSalts: Zoledronate D,L-Lysine Monohydrate
  6. Indication

    Decreased estimated glomerular filtration rate

    go.drugbank.com/conditions/DBCOND0102400
    Drugs: Dapagliflozin · Empagliflozin · Metformin
  7. Indication

    Diet and exercise not sufficient for diabetes control

    go.drugbank.com/conditions/DBCOND0133584
    Drugs: Gliquidone · Metformin · Vildagliptin
  8. Indication

    Previously treated with drugs

    go.drugbank.com/conditions/DBCOND0106247
    Drugs: Eprosartan · Metformin · Vildagliptin
  9. Indication

    Parkinson's Disease (PD)

    go.drugbank.com/conditions/DBCOND0053495
    Drugs: Amantadine · Apomorphine · Benserazide · Biperiden · Bornaprine · Bromocriptine +16 more
    Synonyms: Parkinson&Amp;#39;s Disease
  10. Target

    Creatine Kinases

    go.drugbank.com/bio_entities/BE0009627
    EnzymeTargetHumans

    Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energ...

    Polypeptides: Creatine kinase S-type, mitochondrialSynonyms: S-MtCK