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Displaying results 811 - 820 of 1993 in total
  1. Drug

    Tirasemtiv

    go.drugbank.com/drugs/DB12209
    Investigational

    Tirasemtiv has been used in trials studying the treatment of Myasthenia Gravis, Intermittent Claudication, and Amyotrophic Lateral Sclerosis.

  2. Drug

    XL281

    go.drugbank.com/drugs/DB05190
    Investigational

    XL281 is a novel anticancer compound designed to potently inhibit the RAS/RAF/MEK/ERK signaling pathway.

  3. Drug

    CA-074 methyl ester

    go.drugbank.com/drugs/DB07223
    Experimental

    CA-074 methyl ester (CA-074Me) is a cell-permeable cathepsin B inhibitor. It is converted by cellular esterases to CA-074.

    Synonyms: CA 074 Me ester
  4. Drug

    Scopolamine

    go.drugbank.com/drugs/DB00747
    ApprovedInvestigational

    Scopolamine is a tropane alkaloid isolated from members of the Solanaceae family of plants, similar to atropine and hyoscyamine, all of which structurally mimic the natural neurotransmitter acetylcholine. Scopolamine was first synthesize...

    Mixtures: Me-PB-Hyos, Me-PB-Hyos
  5. Drug

    Abiprubart

    go.drugbank.com/drugs/DB19333
    Investigational

    Abiprubart is being evaluated for its efficacy and safety in participants with Sjögren's Disease in clinical trial NCT06531395

    Synonyms: Immunoglobulin G4-kappa, anti-[Homo sapiens CD40 (TNFRSF5, tumor necrosis factor receptor (TNFR) superfamily member 5, p50)], humanized monoclonal antibody
  6. Target

    Endothelin receptor type B

    go.drugbank.com/bio_entities/BE0000043
    TargetHumans

    Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system

    Polypeptides: Endothelin receptor type BSynonyms: Endothelin receptor non-selective type
  7. Target

    Muscarinic acetylcholine receptor M3

    go.drugbank.com/bio_entities/BE0000045
    TargetHumans

    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action

    Polypeptides: Muscarinic acetylcholine receptor M3
  8. Target

    Muscarinic acetylcholine receptor M1

    go.drugbank.com/bio_entities/BE0000092
    TargetHumans

    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action

    Polypeptides: Muscarinic acetylcholine receptor M1Function: G protein-coupled acetylcholine receptor activity
  9. Target

    Cysteinyl leukotriene receptor 2

    go.drugbank.com/bio_entities/BE0000099
    TargetHumans

    Receptor for cysteinyl leukotrienes. The response is mediated via a G protein that activates a phosphatidylinositol-calcium second messenger system.

    Polypeptides: Cysteinyl leukotriene receptor 2Synonyms: G protein-coupled receptor HG57, G protein-coupled receptor GPCR21
  10. Target

    Lutropin-choriogonadotropic hormone receptor

    go.drugbank.com/bio_entities/BE0000134
    TargetHumans

    Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099)

    Polypeptides: Lutropin-choriogonadotropic hormone receptorSynonyms: Luteinizing hormone receptor