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Displaying results 811 - 820 of 10000 in total
  1. Drug

    VO659

    go.drugbank.com/drugs/DB18160
    Investigational

    VO659 is an antisense oligonucleotide being investigated for the treatment of Huntington's disease.

    Synonyms: an antisense oligonucleotide that has been developed to target expanded CAG repeats in messenger ribonucleic acid (mRNA)
  2. Target

    Calcium/calmodulin-dependent protein kinase type 1

    go.drugbank.com/bio_entities/BE0009417
    TargetHumans

    In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I … Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation

    Synonyms: CaM kinase I, CaM kinase I alpha
  3. Indication

    Sezary Syndrome

    go.drugbank.com/conditions/DBCOND0001518
    Drugs: Doxorubicin · Isotretinoin · Pentostatin
    Synonyms: Cutaneous T-cell lymphoma, no ICD-O subtype, Cutaneous T-cell lymphoma, no International Classification of Diseases for Oncology subtype
  4. Indication

    Squamous Cell Carcinoma (SCC)

    go.drugbank.com/conditions/DBCOND0043488
    Drugs: Bleomycin
    Synonyms: Squamous cell carcinoma, no ICD-O subtype, Squamous cell carcinoma, no International Classification of Diseases for Oncology subtype
  5. Drug

    Cetylpyridinium

    go.drugbank.com/drugs/DB11073
    ApprovedInvestigational

    In these products, it generally mediates an antiseptic activity and protective action against dental plaque and reducing gingivitis. … Its salt form, cetylpyridinium chloride, is typically found as an active ingredient in mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays.

    Mixtures: BUCOSEPTOL N, Emercreme No4 Ont EfaCategories: Compounds used in a research, industrial, or household setting, Heterocyclic Compounds, 1-Ring
  6. Drug

    Somatotropin

    go.drugbank.com/drugs/DB00052
    ApprovedInvestigational

    It has an identical primary protein structure to endogenous human growth hormone.[A228188] Recombinant HGH has been commercially available since 1985 after its development by Genentech. … Human growth hormone (HGH), also known as somatotropin, is a peptide hormone that is synthesized and secreted by the somatotropic cells of the anterior pituitary gland.

    Mixtures: Nutropin - Kit Pws(5mg) & Liq(10ml) Im Sc, Nutropin - Kit Pws(10mg) & Liq(10ml) Im ScCategories: P-glycoprotein substrates, Cytochrome P-450 CYP1A2 Inducers
  7. Drug

    Oxybenzone

    go.drugbank.com/drugs/DB01428
    Approved

    It is used as an ingredient in sunscreen and other cosmetics because it absorbs UV-A ultraviolet rays. … Oxybenzone is an organic compound used in sunscreens. It is a derivative of benzophenone. It forms colorless crystals that are readily soluble in most organic solvents.

    Mixtures: Skin Care Prescription, Fruit Of The Earth Block-UP Sport 30 Bug RepellingCategories: Compounds used in a research, industrial, or household setting
  8. Drug

    Isotretinoin

    go.drugbank.com/drugs/DB00982
    ApprovedInvestigational

    [L6579] The first isotretinoin-containing product was FDA approved on 7 May 1982.[L6574] … Isotretinoin is a retinoid derivative of vitamin A used in the treatment of severe recalcitrant acne.

    Mixtures: ISOTREXIN JEL, 30 G, ETREXİN % 2 + % 0.05 JELCategories: Retinoids for Topical Use in Acne, Cytochrome P-450 Substrates
  9. Drug

    (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE

    go.drugbank.com/drugs/DB07964
    Experimental

    Synonyms: (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE
  10. Drug

    Ticagrelor

    go.drugbank.com/drugs/DB08816
    ApprovedInvestigational

    [A2903] Unlike [clopidogrel], ticagrelor is not a prodrug.[A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] and Brilique or Possia in the EU,[L14207]. … Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y<sub>12</sub> receptor antagonism.

    Categories: P-glycoprotein inhibitors, P-glycoprotein substratesSynonyms: (1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol