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Displaying results 811 - 820 of 10000 in total
  1. Target

    GABA-A gated chloride channel

    go.drugbank.com/bio_entities/BE0009556
    TargetOnchocerca volvulus

  2. Target

    ATP-dependent RNA helicase A

    go.drugbank.com/bio_entities/BE0014303
    TargetHumans

    Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1 (PubMed:11038348, … Plays a role in mRNA translation (PubMed:28355180).

    Polypeptides: ATP-dependent RNA helicase ASynonyms: RNA helicase A
  3. Drug

    Oryctolagus cuniculus skin

    go.drugbank.com/drugs/DB10607
    Approved

    Oryctolagus cuniculus skin or pelt is used in allergenic testing.

    Synonyms: European rabbit skin extract
  4. Drug

    Lanreotide

    go.drugbank.com/drugs/DB06791
    ApprovedInvestigational

    This drug is a long-acting analog of the drug somatostatin, a growth hormone inhibitor. … Lanreotide is a drug employed in the management of acromegaly (a hormonal condition caused by excess growth hormone) in addition to symptoms caused by neuroendocrine tumors, especially carcinoid syndrome

    Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 InhibitorsProducts: Somatuline Autogel Prolonged Release Solution for Injection in a Pre-filled Syringe 120 mg, Somatuline Autogel Prolonged Release Solution for Injection in a Pre-filled Syringe 60 mg
  5. Target

    Acetyl-coenzyme A synthetase, cytoplasmic

    go.drugbank.com/bio_entities/BE0000350
    TargetEnzymeHumans

    Can also utilize propionate with a much lower affinity (PubMed:38369012). Catalyzes the conversion of lactate into lactoyl-CoA (PubMed:39561764). … Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (By similarity).

    Polypeptides: Acetyl-coenzyme A synthetase, cytoplasmic
  6. Target

    Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

    go.drugbank.com/bio_entities/BE0000377
    TargetHumans

    Plays a role in the maintenance of normal spermatogenesis through the reduction of fatty acid accumulation in the testes (By similarity) … Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion

    Polypeptides: Hydroxyacyl-coenzyme A dehydrogenase, mitochondrialSynonyms: Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase
  7. Target

    Ephrin type-A receptor 2

    go.drugbank.com/bio_entities/BE0000841
    TargetHumans

    With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis … May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration.

    Polypeptides: Ephrin type-A receptor 2
  8. Target

    Ribose-5-phosphate isomerase A

    go.drugbank.com/bio_entities/BE0001557
    TargetThermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

    Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.

    Polypeptides: Ribose-5-phosphate isomerase ASynonyms: Phosphoriboisomerase A
  9. Target

    Inositol-trisphosphate 3-kinase A

    go.drugbank.com/bio_entities/BE0001627
    TargetHumans

    Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis

    Polypeptides: Inositol-trisphosphate 3-kinase ASynonyms: IP3K A, IP3 3-kinase A
  10. Target

    Complement C1q subcomponent subunit A

    go.drugbank.com/bio_entities/BE0002094
    TargetHumans

    The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM (PubMed:19706439, PubMed:24626930, PubMed:29449492). … Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens

    Polypeptides: Complement C1q subcomponent subunit A