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Vinorelbine
go.drugbank.com/drugs/DB00361ApprovedInvestigationalIt was initially approved in the USA in 1990's for the treatment of NSCLC [L2010]. It is a third-generation vinca alkaloid. … A study was done on the clearance rate of vinorelbine on individuals with various single polymorphonuclear mutations.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesSynonyms: 5'-NoranhydrovinblastineGrepafloxacin
go.drugbank.com/drugs/DB00365ApprovedWithdrawnGrepafloxacin is an oral broad-spectrum quinoline antibacterial agent used to treat bacterial infections. Due to the QTc-prolonging potential, as indicated by the changes in the QT interval on the electrocardiogram, and the risk for card...
Categories: 4-Quinolones, P-glycoprotein inhibitorsDoxylamine
go.drugbank.com/drugs/DB00366ApprovedInvestigationalVet approvedHistamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.
Mixtures: N - Time, ®Categories: Heterocyclic Compounds, 1-RingPalonosetron
go.drugbank.com/drugs/DB00377ApprovedInvestigationalAs of 2008, it is the most recent 5-HT3 antagonist to enter clinical use. … It is the most effective of the 5-HT3 antagonists in controlling delayed CINV nausea and vomiting that appear more than 24 hours after the first dose of a course of chemotherapy and is the only drug of
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingSynonyms: 2-(1-Azabicyclo(2.2.2)oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benz(de)isoquinolin-1-one, (3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-oneDexrazoxane
go.drugbank.com/drugs/DB00380ApprovedInvestigationalWithdrawnIt appears to inhibit formation of a toxic iron-anthracycline complex.
Categories: Heterocyclic Compounds, 1-Ring, Compounds used in a research, industrial, or household settingSynonyms: 2,6-Piperazinedione, 4, 4'-(1-methyl-1,2-ethanediyl)bis-, (S)- (9CI), 2, 6-Piperazinedione, 4,4'-propylenedi-, (P)- (8CI)Triamterene
go.drugbank.com/drugs/DB00384ApprovedTriamterene (2,4,7-triamino-6-phenylpteridine) is a potassium-sparing diuretic that is used in the management of hypertension. … Triamterene is a weak antagonist of folic acid, and a photosensitizing drug.[L6163] Triamterene was approved by the Food and Drug Administration in the U.S. in 1964.
Mixtures: DYTIDE H, DYTIDE HCategories: Cytochrome P-450 Substrates, Decreased Renal K+ ExcretionPhenylephrine
go.drugbank.com/drugs/DB00388ApprovedInvestigationalPhenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension,[L9416,L9410] dilate the pupil,[L9413] and induce local vasoconstriction.
Mixtures: L M 6, K-Y-6Categories: Adrenergic alpha-1 Receptor Agonists, Monoamine Oxidase A SubstratesProfenamine
go.drugbank.com/drugs/DB00392ApprovedProfenamine (also known as ethopropazine) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat Parkinsonism.
Categories: Heterocyclic Compounds, 3-RingSynonyms: N,N-diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine, 2-diethylamino-1-propyl-N-dibenzoparathiazineNimodipine
go.drugbank.com/drugs/DB00393ApprovedInvestigationalNimodipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-methoxyethyl ester 5-isopropyl ester, isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylateBeclomethasone dipropionate
go.drugbank.com/drugs/DB00394ApprovedInvestigationalBeclomethasone dipropionate became first available in a pressurized metered-dose inhaler in 1972 and later in a dry powder inhaler and an aqueous nasal spray. … Beclomethasone dipropionate is a second-generation[A179842] synthetic corticosteroid and diester of beclomethasone, which is structurally similar to [dexamethasone].
Synonyms: (11β,16β)-9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione, 9-chloro-11β-hydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionateInternational brands: Clenil-A