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DNA topoisomerase 4 subunit A
go.drugbank.com/bio_entities/BE0000798TargetEscherichia coli (strain K12)MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation (PubMed:20921377).
Polypeptides: DNA topoisomerase 4 subunit ASynonyms: Topoisomerase IV subunit ARibose-5-phosphate isomerase A
go.drugbank.com/bio_entities/BE0001628TargetShigella flexneriCatalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
Polypeptides: Ribose-5-phosphate isomerase ASynonyms: Phosphoriboisomerase AGlyceraldehyde-3-phosphate dehydrogenase A
go.drugbank.com/bio_entities/BE0002057TargetEscherichia coli (strain K12)The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction … The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.
Polypeptides: Glyceraldehyde-3-phosphate dehydrogenase ASynonyms: GAPDH-AEndo-1,4-beta-xylanase A
go.drugbank.com/bio_entities/BE0002766TargetStreptomyces lividansContributes to hydrolyze hemicellulose, the major component of plant cell-walls. XLNA and XLNB seem to act sequentially on the substrate to yield xylobiose and xylose as carbon sources.
Polypeptides: Endo-1,4-beta-xylanase ASynonyms: Xylanase A, 1,4-beta-D-xylan xylanohydrolase ARibose-5-phosphate isomerase A
go.drugbank.com/bio_entities/BE0003268TargetHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
Polypeptides: Ribose-5-phosphate isomerase ASynonyms: Phosphoriboisomerase AEphrin type-A receptor 7
go.drugbank.com/bio_entities/BE0004140TargetHumansAmong GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. … May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity.
Polypeptides: Ephrin type-A receptor 7Acyl-coenzyme A thioesterase 13
go.drugbank.com/bio_entities/BE0004376TargetHumansMay play a role in controlling adaptive thermogenesis (By similarity) … Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16934754, PubMed:19170545).
Polypeptides: Acyl-coenzyme A thioesterase 13Ras-related protein Ral-A
go.drugbank.com/bio_entities/BE0004562TargetHumansMultifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. … Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108).
Polypeptides: Ras-related protein Ral-ASerum amyloid A-1 protein
go.drugbank.com/bio_entities/BE0004795TargetHumansMajor acute phase protein
Polypeptides: Serum amyloid A-1 proteinEphrin type-A receptor 3
go.drugbank.com/bio_entities/BE0009437TargetHumansHighly promiscuous for ephrin-A ligands it binds preferentially EFNA5 (By similarity). … Also activated by EFNA1, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development (PubMed:12794130). Involved in the retinotectal mapping of neurons.
Polypeptides: Ephrin type-A receptor 3