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Displaying results 841 - 850 of 1186 in total
  1. Target

    Acetylcholine receptor subunit alpha-type unc-63

    go.drugbank.com/bio_entities/BE0004926
    TargetCaenorhabditis elegans

    Alpha subunit of nicotinic acetylcholine receptor (nAChR) (PubMed:15280391, PubMed:15990870, PubMed:20027209).

    Polypeptides: Acetylcholine receptor subunit alpha-type unc-63
  2. Target

    G protein-coupled bile acid receptor 1

    go.drugbank.com/bio_entities/BE0005788
    TargetHumans

    G protein-coupled receptor for bile acid (PubMed:12419312, PubMed:12524422, PubMed:32698187, PubMed:32747649, PubMed:35858343).

    Polypeptides: G protein-coupled bile acid receptor 1Synonyms: G protein-coupled receptor GPCR19, Membrane-type receptor for bile acids
  3. Target

    Lymphatic vessel endothelial hyaluronic acid receptor 1

    go.drugbank.com/bio_entities/BE0010044
    TargetHumans

    Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding ...

    Polypeptides: Lymphatic vessel endothelial hyaluronic acid receptor 1Synonyms: Hyaluronic acid receptor
  4. Target

    Nuclear receptor subfamily 4immunitygroup A member 1

    go.drugbank.com/bio_entities/BE0010494
    TargetHumans

    Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (PubMed:18690216, PubMed:8121493, PubMed:9315652).

    Polypeptides: Nuclear receptor subfamily 4immunitygroup A member 1Synonyms: Testicular receptor 3, Orphan nuclear receptor HMR
  5. Target

    Tumor necrosis factor receptor superfamily member 18

    go.drugbank.com/bio_entities/BE0010519
    TargetHumans

    Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death.

    Polypeptides: Tumor necrosis factor receptor superfamily member 18Synonyms: Activation-inducible TNFR family receptor
  6. Target

    Low-density lipoprotein receptor-related protein 6

    go.drugbank.com/bio_entities/BE0012061
    TargetHumans

    Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes (PubMed:11357136, PubMed:11448771

    Polypeptides: Low-density lipoprotein receptor-related protein 6
  7. Target

    Tyrosine-protein phosphatase non-receptor type 2

    go.drugbank.com/bio_entities/BE0012706
    TargetHumans

    Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. … May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis.

    Polypeptides: Tyrosine-protein phosphatase non-receptor type 2
  8. Target

    Tumor necrosis factor receptor superfamily member EDAR

    go.drugbank.com/bio_entities/BE0021253
    TargetHumans

    Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death

    Polypeptides: Tumor necrosis factor receptor superfamily member EDARSynonyms: EDA-A1 receptor, Ectodysplasin-A receptor
  9. Target

    T cell receptor beta variable 6-5

    go.drugbank.com/bio_entities/BE0021562
    TargetHumans

    V region of the variable domain of T cell receptor (TR) beta chain that participates in the antigen recognition (PubMed:24600447).

    Polypeptides: T cell receptor beta variable 6-5
  10. Drug

    Erlotinib

    go.drugbank.com/drugs/DB00530
    ApprovedInvestigational

    Recent studies demonstrate that erlotinib is also a potent inhibitor of JAK2V617F, which is a mutant form of tyrosine kinase JAK2 found in most patients with polycythemia vera (PV) and a substantial proportion … Erlotinib binds to the epidermal growth factor receptor (EGFR) tyrosine kinase in a reversible fashion at the adenosine triphosphate (ATP) binding site of the receptor.

    Categories: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors