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Displaying results 841 - 850 of 1203 in total
  1. Target

    G protein-coupled receptor kinase 5

    go.drugbank.com/bio_entities/BE0013072
    TargetHumans

    Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. … Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor, LRP6 during Wnt signaling (in vitro)

    Polypeptides: G protein-coupled receptor kinase 5Synonyms: G protein-coupled receptor kinase GRK5
  2. Target

    Interleukin-12 receptor subunit beta-1

    go.drugbank.com/bio_entities/BE0013218
    TargetHumans

    Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. … Also associates with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade

    Polypeptides: Interleukin-12 receptor subunit beta-1Synonyms: IL-12 receptor beta component, IL-12 receptor subunit beta-1
  3. Target

    Short transient receptor potential channel 1

    go.drugbank.com/bio_entities/BE0013282
    TargetHumans

    Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11139478, PubMed:15016832, PubMed:39478185).

    Polypeptides: Short transient receptor potential channel 1Synonyms: Transient receptor protein 1
  4. Target

    Interleukin-12 receptor subunit beta-2

    go.drugbank.com/bio_entities/BE0018860
    TargetHumans

    Receptor for interleukin-12. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. Promotes the proliferation of T-cells as well as NK cells.

    Polypeptides: Interleukin-12 receptor subunit beta-2Synonyms: IL-12 receptor subunit beta-2
  5. Target

    Taste receptor type 2 member 10

    go.drugbank.com/bio_entities/BE0020463
    TargetHumans

    Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract.

    Polypeptides: Taste receptor type 2 member 10Synonyms: Taste receptor family B member 2
  6. Target

    Short transient receptor potential channel 4

    go.drugbank.com/bio_entities/BE0020751
    TargetHumans

    Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11042129, PubMed:11713258, PubMed:16144838, PubMed:39478185).

    Polypeptides: Short transient receptor potential channel 4
  7. Target

    Short transient receptor potential channel 5

    go.drugbank.com/bio_entities/BE0021113
    TargetHumans

    Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:16284075, PubMed:38959890, PubMed:37137991).

    Polypeptides: Short transient receptor potential channel 5Synonyms: Transient receptor protein 5
  8. Target

    Taste receptor type 2 member 14

    go.drugbank.com/bio_entities/BE0023216
    TargetHumans

    Gustducin-linked G protein-coupled receptor that plays a role in the perception of bitterness (PubMed:38600377, PubMed:38776963). … The activity of this receptor stimulates GNAT3, activating the gustducin G protein pathway (PubMed:38600377, PubMed:38776963).

    Polypeptides: Taste receptor type 2 member 14Synonyms: Taste receptor family B member 1
  9. Drug

    Carfentanil

    go.drugbank.com/drugs/DB01535
    IllicitInvestigationalVet approved

    Carfentanil or carfentanyl (Wildnil) is an analogue of the popular synthetic opioid analgesic fentanyl, and is one of the most potent opioids known (also the most potent opioid used commercially). Carfentanil was first synthesized in 197...

  10. Drug

    3-Methylfentanyl

    go.drugbank.com/drugs/DB01571
    ExperimentalIllicit

    3-Methylfentanyl is an opioid analgesic and is an analog of the potent opioid, fentanyl. 3-Methylfentanyl is one of the most powerful opioid drugs sold illegally and is estimated to be between 400-6000 times more potent than morphine in ...