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Vardenafil
go.drugbank.com/drugs/DB00862ApprovedVardenafil is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5) and an oral therapy for the treatment of erectile dysfunction. … [A258313] The use of vardenafil as a monotherapy for the treatment of pulmonary arterial hypertension has also been evaluated.[A258308]
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: Vardenafil 1 A Pharma 5 mg - Filmtabletten, เลวิตรา(R) 5Alprenolol
go.drugbank.com/drugs/DB00866ApprovedWithdrawnOne of the adrenergic beta-antagonists used as an antihypertensive, anti-anginal, and anti-arrhythmic agent. Alprenolol is no longer marketed by AstraZeneca, but may still be available in generic varieties.
Synonyms: (RS)-1-(2-allylphenoxy)-3-(isopropylamino)propan-2-ol, 1-(2-Allylphenoxy)-3-isopropylamino-2-propanolCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 SubstratesFlupentixol
go.drugbank.com/drugs/DB00875ApprovedInvestigationalWithdrawnIt exists in two geometric isomers, the trans(E) and pharmacologically active cis(Z) forms. … Flupentixol decanoate is one of the active ingredients found in injectable drug formulations: it is produced by esterification of cis(Z)‐flupentixol with decanoic acid.
Categories: P-glycoprotein inhibitors, Heterocyclic Compounds, 1-RingProducts: ฟูลแอนซอล 3 มก., FLUANXOL 1 MGEprosartan
go.drugbank.com/drugs/DB00876ApprovedInvestigationalIt performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs.
Mixtures: EPROSARTAN E IDROCLOROTIAZIDE MYLAN, EPROSARTAN E IDROCLOROTIAZIDE MYLANCategories: Angiotensin 2 Receptor Blocker, Heterocyclic Compounds, 1-RingChlorhexidine
go.drugbank.com/drugs/DB00878ApprovedInvestigationalVet approvedWithdrawn[A190417] The molecule itself is a cationic bis-guanide consisting of two 4-chlorophenyl rings and two biguanide groups joined by a central hexamethylene chain. … Chlorhexidine is a broad-spectrum antimicrobial biguanide used as a topical antiseptic and in dental practice for the treatment of inflammatory dental conditions caused by microorganisms.
Synonyms: N,N'-Bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide, 1,1'-Hexamethylene bis(5-(p-chlorophenyl)biguanide)International brands: Prevacare REmtricitabine
go.drugbank.com/drugs/DB00879ApprovedInvestigational[L9019] Emtricitabine was granted FDA approval on 2 July 2003.[L9019] … Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) indicated for the treatment of HIV infection in adults[L9019] or combined with [tenofovir alafenamide] for the prevention of HIV-1 infection
Mixtures: TOLAK® E 300/200, TOLAK® E 300/200Categories: MATE 1 Substrates, Heterocyclic Compounds, 1-RingQuinapril
go.drugbank.com/drugs/DB00881ApprovedInvestigational[L8420] A combination tablet with [hydrochlorothiazide] was also approved on 28 December 1999.[L8423] … [L8420,L8423] ACE inhibitors are commonly used as a first line therapy in the treatment of hypertension, along with thiazide diuretics or beta blockers.
Mixtures: QUINAPRIL E IDROCLOROTIAZIDE ACTAVIS, QUINAPRIL E IDROCLOROTIAZIDE MYLAN GENERICSCategories: Heterocyclic Compounds, 2-RingClomifene
go.drugbank.com/drugs/DB00882ApprovedInvestigationalA triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Categories: P-glycoprotein substratesSynonyms: 2-(4-(2-chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine, 2-(p-(β-chloro-α-phenylstyryl)phenoxy)triethylamineMechlorethamine
go.drugbank.com/drugs/DB00888ApprovedInvestigationalA vesicant and necrotizing irritant destructive to mucous membranes, mechlorethamine is an alkylating drug. It was formerly used as a war gas. … The FDA granted marketing approval for the orphan drug Valchlor (mechlorethamine) gel on August 23, 2013 for the topical treatment of stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma (CTCL
Categories: Compounds used in a research, industrial, or household settingSynonyms: β,β'-dichlorodiethyl-N-methylamine, N-methyl-bis(2-chloroethyl)amineSulfapyridine
go.drugbank.com/drugs/DB00891ApprovedWithdrawnAntibacterial, potentially toxic, and previously used to treat certain skin diseases. No longer prescribed.
Synonyms: N(1)-2-Pyridylsulfanilamide, 4-Amino-N,2-pyridinylbenzenesulfonamideCategories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme Inhibitors