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Arecoline
go.drugbank.com/drugs/DB04365ExperimentalAn alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. It is an agonist at both muscarinic and nicotinic acetylcholine receptors.
Hydroxychloroquine
go.drugbank.com/drugs/DB01611ApprovedInvestigational[L8072] A recent study reported a fatality in the group being treated with hydroxychloroquine for COVID-19.[A192546]
Lemborexant
go.drugbank.com/drugs/DB11951ApprovedInvestigational[L10863] Recent research in the field of sleep disorders has revealed that insomnia is likely driven not by the inability of the brain to "switch on" sleep-related circuits, but rather an inability to … Lemborexant is a novel dual orexin receptor antagonist used in the treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.
Categories: Orexin Receptor AntagonistsHigh affinity immunoglobulin epsilon receptor subunit alpha
go.drugbank.com/bio_entities/BE0000015TargetHumansHigh-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells.
Polypeptides: High affinity immunoglobulin epsilon receptor subunit alphaSynonyms: IgE Fc receptor subunit alphaHigh affinity immunoglobulin gamma Fc receptor I
go.drugbank.com/bio_entities/BE0000710TargetCarrierHumansHigh affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses.
Polypeptides: High affinity immunoglobulin gamma Fc receptor ISynonyms: IgG Fc receptor IGamma-aminobutyric acid receptor subunit alpha-6
go.drugbank.com/bio_entities/BE0000764TargetHumansAlpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:8632757). GABA-gated chloride channels, also named GABA(A) receptors (G...
Polypeptides: Gamma-aminobutyric acid receptor subunit alpha-6Synonyms: GABA(A) receptor subunit alpha-6Tyrosine-protein phosphatase non-receptor type 4
go.drugbank.com/bio_entities/BE0000980TargetHumansPhosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:25825441, PubMed:27246854). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (PubMed:20086240). Negatively re...
Polypeptides: Tyrosine-protein phosphatase non-receptor type 4Tumor necrosis factor receptor superfamily member 1A
go.drugbank.com/bio_entities/BE0001139TargetHumansReceptor for TNFSF2/TNF and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor.
Polypeptides: Tumor necrosis factor receptor superfamily member 1ASynonyms: Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type ITriggering receptor expressed on myeloid cells 1
go.drugbank.com/bio_entities/BE0001288TargetHumansBy also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute … Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102).
Polypeptides: Triggering receptor expressed on myeloid cells 1Synonyms: Triggering receptor expressed on monocytes 1Gamma-aminobutyric acid receptor subunit beta-1
go.drugbank.com/bio_entities/BE0002344TargetHumansBeta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:10449790, PubMed:16412217, PubMed:26950270). GABA-gated chloride channel...
Polypeptides: Gamma-aminobutyric acid receptor subunit beta-1Synonyms: GABA(A) receptor subunit beta-1