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Etrasimod
go.drugbank.com/drugs/DB14766ApprovedInvestigational[A261826] In fact, it has been observed that antigen-activated T cells within peripheral lymphoid organs can transiently downregulate S1P receptor levels to facilitate immune cells trafficking into the … [A261831] Etrasimod was approved on October 13, 2023, by the FDA under the brand name VELSIPITY for the treatment of adults with moderately to severely active ulcerative colitis.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingDNA-3-methyladenine glycosylase 1
go.drugbank.com/bio_entities/BE0001657TargetEscherichia coli (strain K12)Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions.
Synonyms: TAG I, DNA-3-methyladenine glycosidase IOlmesartan
go.drugbank.com/drugs/DB00275ApprovedInvestigationalangiotensin I to angiotensin II through inhibition of the ACE enzyme. … [A175330] It was developed by Daiichi Sankyo Pharmaceuticals and approved in 2002.[A175345, L12882]
Mixtures: OPENVAS CO, ALMETEC-COCategories: Agents Acting on the Renin-Angiotensin System, Angiotensin II receptor antagonistsRisperidone
go.drugbank.com/drugs/DB00734ApprovedInvestigational[L12885] Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways … Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, P-glycoprotein substratesInternational brands: Risperidal M-TabInsulin-like growth factor 1 receptor
go.drugbank.com/bio_entities/BE0000858TargetHumansJNK kinases can also be activated by the IGF1R. … Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins.
Synonyms: IGF-I receptor, Insulin-like growth factor I receptorDNA-binding transcriptional regulator NtrC
go.drugbank.com/bio_entities/BE0001282TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open p...
Synonyms: Nitrogen regulator I, Nitrogen regulation protein NR(I)Apolipoprotein L1
go.drugbank.com/bio_entities/BE0009069TargetHumansMay play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. A component of trypanosome lytic factor of human serum; plays a crucial role in kil...
Synonyms: ApoL-I, Apolipoprotein L-IGeranylgeranyl transferase type-1 subunit beta
go.drugbank.com/bio_entities/BE0001142TargetHumansCatalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include...
Synonyms: GGTase-I-beta, Geranylgeranyl transferase type I subunit beta