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Displaying results 871 - 880 of 10000 in total
  1. Drug

    Ginkgo biloba

    go.drugbank.com/drugs/DB01381
    ApprovedInvestigationalNutraceutical

    [A232404] EGb761 contains 6% terpene lactones and 24% flavonoid glycosides.[A232379] Flavonoids include quercetin, rutin, kaempferol, and isorhamnetin. … _Ginkgo biloba_ is found in a number of homeopathic and over-the-counter herbal products and dietary supplements, but it has no approved therapeutic indications by regulatory bodies, such as the FDA, EMA

    Mixtures: DOMINGO 5/5/80 MG EFERVESAN TABLET, 30 ADET, DOMINGO 5/5/80 MG EFERVESAN TABLET, 90 ADETCategories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Cytochrome P-450 CYP1A2 Inhibitors
  2. Drug

    Malathion

    go.drugbank.com/drugs/DB00772
    Approved

    Malathion is a parasympathomimetic organophosphate compound that is used as an insecticide for the treatment of head lice. … Malathion is an irreversible cholinesterase inhibitor and has low human toxicity.

    Categories: Compounds used in a research, industrial, or household setting, Cytochrome P-450 SubstratesSynonyms: O,O-dimethyl S-(1,2-bis(ethoxycarbonyl)ethyl), O,O-dimethyl S-1,2-di(ethoxycarbamyl)ethyl
  3. Drug

    House dust

    go.drugbank.com/drugs/DB10345
    Approved

    House dust allergenic extract is used in allergenic testing.

    Products: A. Dust, AP House Dust Mix
  4. Indication

    Ankle spasticity following a stroke or traumatic brain injury

    go.drugbank.com/conditions/DBCOND0133858
    Drugs: Clostridium botulinum
    Synonyms: Ankle spasticity following a stroke or traumatic brain injury
  5. Target

    3-hydroxy-3-methylglutaryl-coenzyme A reductase

    go.drugbank.com/bio_entities/BE0000574
    TargetEnzymeHumans

    HMGCR is the main target of statins, a class of cholesterol-lowering drugs (PubMed:11349148, PubMed:18540668, PubMed:36745799) … Catalyzes the conversion of (3S)-hydroxy-3-methylglutaryl-CoA (HMG-CoA) to mevalonic acid, the rate-limiting step in the synthesis of cholesterol and other isoprenoids, thus plays a critical role in cellular

    Polypeptides: 3-hydroxy-3-methylglutaryl-coenzyme A reductaseFunction: coenzyme A binding
  6. Target

    Acetyl-coenzyme A synthetase 2-like, mitochondrial

    go.drugbank.com/bio_entities/BE0000746
    TargetHumans

    Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity) … Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity).

    Polypeptides: Acetyl-coenzyme A synthetase 2-like, mitochondrial
  7. Target

    2-amino-3-ketobutyrate coenzyme A ligase

    go.drugbank.com/bio_entities/BE0002049
    TargetEscherichia coli (strain K12)

    Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.

    Polypeptides: 2-amino-3-ketobutyrate coenzyme A ligase
  8. Target

    2,5-diketo-D-gluconic acid reductase A

    go.drugbank.com/bio_entities/BE0002618
    TargetCorynebacterium sp. (strain ATCC 31090)

    Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates. 25DKGR-A exhibits a greater selectivity

    Polypeptides: 2,5-diketo-D-gluconic acid reductase ASynonyms: 2,5-DKG reductase A
  9. Target

    A-type voltage-gated potassium channel KCND2

    go.drugbank.com/bio_entities/BE0003603
    TargetHumans

    Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). … In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes.

    Polypeptides: A-type voltage-gated potassium channel KCND2Function: A-type (transient outward) potassium channel activity
  10. Target

    A-type voltage-gated potassium channel KCND3

    go.drugbank.com/bio_entities/BE0003604
    TargetHumans

    In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). … Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (PubMed:10200233, PubMed:17187064, PubMed

    Polypeptides: A-type voltage-gated potassium channel KCND3Function: A-type (transient outward) potassium channel activity