Search
Simvastatin
go.drugbank.com/drugs/DB00641ApprovedInvestigationalwere found in clinical studies to result in a 45.8% to 54.6% decrease in LDL cholesterol levels, while simvastatin has been found to have an average decrease in LDL-C of ~35%. … It belongs to the statin class of medications, which are used to lower the risk of cardiovascular disease and manage abnormal lipid levels by inhibiting the endogenous production of cholesterol in the
Mixtures: TIAZOMET S®, TIAZOMET S®Categories: P-glycoprotein inhibitors, P-glycoprotein substratesAzithromycin
go.drugbank.com/drugs/DB00207ApprovedInvestigationalIn March 2020, a small study was funded by the French government to investigate the treatment of COVID-19 with a combination of azithromycin and the anti-malaria drug [hydroxychloroquine]. … It is structurally related to erythromycin [A174169].
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesProducts: Zithromax Cap 250mg, ZITHROMAX TR-SAFT K B 25KGVitamin D
go.drugbank.com/drugs/DB11094ApprovedInvestigationalNutraceuticalVet approvedSince vitamin D can be endogenously synthesized in adequate amounts by most mammals exposed to sufficient quantities of sunlight, vitamin D functions like a hormone on vitamin D receptors to regulate calcium … Vitamin D3 and D2 require hydroxylation in order to become biologically active in the human body.
Synonyms: Vitamin D NOS, D VitaminMixtures: Super Daily No 2, Multi Plex I - TabCutaneous Squamous Cell Carcinoma (CSCC)
go.drugbank.com/conditions/DBCOND0168836Drugs: CemiplimabSynonyms: Squamous cell carcinoma, no ICD-O subtype, Squamous cell carcinoma, no International Classification of Diseases for Oncology subtypeMepivacaine
go.drugbank.com/drugs/DB00961ApprovedInvestigationalVet approvedA local anesthetic that is chemically related to bupivacaine but pharmacologically related to lidocaine. It is indicated for infiltration, nerve block, and epidural anesthesia. … Mepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Mixtures: Carbocaine 2% With Neo-cobefrin, Carbocaine 2% With Neo-cobefrinCategories: Heterocyclic Compounds, 1-RingDNA-3-methyladenine glycosylase 1
go.drugbank.com/bio_entities/BE0001657TargetEscherichia coli (strain K12)Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions.
Synonyms: TAG I, DNA-3-methyladenine glycosidase IPerindopril
go.drugbank.com/drugs/DB00790ApprovedInvestigationalPerindoprilat is a potent, competitive inhibitor of ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). … It is rapidly metabolized in the liver to perindoprilat, its active metabolite, following oral administration.
Synonyms: (2S,3aS,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxopentan-2-yl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acidMixtures: COVERATRIX 5 MG/1.25 MG/10 MG COMPRIMIDOS RECUBIERTOS CON PELÍCULA, COVERATRIX 10 MG / 2.5 MG / 5 MG COMPRIMIDOS RECUBIERTOS CON PELÍCULANovobiocin
go.drugbank.com/drugs/DB01051ApprovedInvestigationalVet approvedWithdrawnNovobiocin is an antibiotic compound derived from _Streptomyces niveus_. It has a chemical structure similar to coumarin. … Novobiocin binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity.
Categories: Coumarins, Heterocyclic Compounds, 1-RingSynonyms: N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-β-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-chromen-3-yl}-4-hydroxy-3-(3-methylbut-2-en-1-yl)benzamide