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Displaying results 81 - 90 of 605 in total
  1. Target

    BCL11 transcription factor A

    go.drugbank.com/bio_entities/BE0019545
    TargetHumans

    Transcription factor (PubMed:16704730, PubMed:29606353). Associated with the BAF SWI/SNF chromatin remodeling complex (PubMed:23644491, PubMed:39607926). … Essential factor in lymphopoiesis required for B-cell formation in fetal liver (By similarity). May function as a modulator of the transcriptional repression activity of NR2F2 (By similarity)

    Polypeptides: BCL11 transcription factor AFunction: DNA-binding transcription factor activity
  2. Target

    Fibroblast growth factor 21

    go.drugbank.com/bio_entities/BE0020031
    TargetHumans

    Regulates systemic glucose homeostasis and insulin sensitivity

    Polypeptides: Fibroblast growth factor 21Function: fibroblast growth factor receptor binding
  3. Target

    Fibroblast growth factor 4

    go.drugbank.com/bio_entities/BE0000326
    TargetHumans

    Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. … May play a role in embryonic molar tooth bud development via inducing the expression of MSX1, MSX2 and MSX1-mediated expression of SDC1 in dental mesenchyme cells (By similarity)

    Polypeptides: Fibroblast growth factor 4Synonyms: Heparin-binding growth factor 4
  4. Target

    Epidermal growth factor receptor

    go.drugbank.com/bio_entities/BE0000767
    TargetEnzymeHumans

    Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). … Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (PubMed:10026169, PubMed:17349580, PubMed:18046415, PubMed:19560417, PubMed:19836242

    Polypeptides: Epidermal growth factor receptor
  5. Target

    Hepatocyte growth factor receptor

    go.drugbank.com/bio_entities/BE0000915
    TargetHumans

    Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. … During embryonic development, MET signaling plays a role in gastrulation, development and migration of neuronal precursors, angiogenesis and kidney formation.

    Polypeptides: Hepatocyte growth factor receptorSynonyms: Scatter factor receptor
  6. Target

    Complement decay-accelerating factor

    go.drugbank.com/bio_entities/BE0000929
    TargetHumans

    Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the … This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation.

    Polypeptides: Complement decay-accelerating factor
  7. Target

    Beta-nerve growth factor

    go.drugbank.com/bio_entities/BE0001094
    TargetHumans

    Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:14976160, PubMed:20978020). … The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2

    Polypeptides: Beta-nerve growth factorFunction: growth factor activity
  8. Target

    Release factor glutamine methyltransferase

    go.drugbank.com/bio_entities/BE0002051
    TargetEscherichia coli (strain K12)

    Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif, i.e. on 'Gln-235' in RF1 and on 'Gln-252' in RF2.

    Polypeptides: Release factor glutamine methyltransferaseSynonyms: Protein release factor methylation C
  9. Target

    ADP-ribosylation factor 1

    go.drugbank.com/bio_entities/BE0003814
    TargetHumans

    Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (By similarity). … The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (PubMed:8253837).

    Polypeptides: ADP-ribosylation factor 1
  10. Target

    ADP-ribosylation factor 6

    go.drugbank.com/bio_entities/BE0004242
    TargetHumans

    Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization (PubMed:36017701). … Plays a role in the reorganization of the actin cytoskeleton and the formation of stress fibers (By similarity).

    Polypeptides: ADP-ribosylation factor 6