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Clofedanol H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174961Drug actionChlophedianol is an H1-antihistamine cough suppressant. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as aller...
Chlorprothixene H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174962Drug actionChlorprothixene is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. H1-antihist...
Cariprazine H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174972Drug actionCariprazine is an H1-antihistamine. H1-antihistamines interfere with the agonist action of histamine at the H1 receptor and are administered to attenuate inflammatory process in order to treat conditions such as allergic rhinitis, allerg...
Benzquinamide H1 Antihistamine Smooth Muscle Relaxation Action Pathway
smpdb.ca/view/SMP0174975Drug actionBenzquinamide is a discontinued antiemetic compound with antihistaminic, mild anticholinergic, and sedative properties. The mechanism of action is not known, but presumably benzquinamide works via antagonism of muscarinic acetycholine re...
Sphingolipid Signaling
smpdb.ca/view/SMP0538962SignalingIn eukaryotic cells, sphingolipid metabolism begins in the endoplasmic reticulum (ER) with serine palmitoyltransferase (SPT) catalyzing the condensation of serine and palmitoyl‑CoA to generate 3‑ketodihydrosphingosine, which is rapidly r...
Sorafenib Action Pathway
smpdb.ca/view/SMP0122742Drug actionSorafenib, marketed as Nexavar, is a drug for the treatment of advanced renal cell carcinoma (primary kidney cancer). It is an inhibitor of the RAF kinase protein and cell surface kinases PDGF-beta receptor, VEGF 2 and 3 receptor (many s...
Didanosine Anti-viral Action Pathway
smpdb.ca/view/SMP0124953Drug actionDidanosine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). When HIV infects a cell, the virus first binds and fuses with the cell, releasing its nucleocapsid conta...
Prazosin Action Pathway
smpdb.ca/view/SMP0125086Drug actionPrazosin is an alpha-blocker that causes a decrease in total peripheral resistance and is used to treat hypertension. This drug is indicated for the treatment of hypertension (high blood pressure). Prazosin can be given alone or given wi...
Tamsulosin Action Pathway
smpdb.ca/view/SMP0125129Drug actionTamsulosin is an alpha-1A and alpha-1B adrenergic receptor antagonist used to treat benign prostatic hyperplasia, ureteral stones, prostatitis, and female voiding dysfunction. Tamsulosin is a blocker of alpha-1A and alpha-1D adrenoceptor...
Oxybutynin Action Pathway
smpdb.ca/view/SMP0125281Drug actionOxybutynin is an antimuscarinic agent that relaxes the muscles of the bladder, and prevents the urge to void. This helps with conditions such as bladder spasms and overactive bladder syndrome (OABS). Oxybutynin is an agonist of muscarini...