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Triamterene Action Pathway (New)
smpdb.ca/view/SMP0126281Drug actionTriamterene maintains or increases sodium excretion, thereby increasing the excretion of water, and reducing the excess loss of potassium, hydrogen, and chloride ions by inhibiting the distal tubular exchange … sodium uptake and potassium secretion.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Ethacrynic Acid Diuretic Action Pathway
smpdb.ca/view/SMP0124515Drug actionThis is relieves symptoms such as swelling/ edema and hypertension in patients. Ethacrynic acid may also inhibit sodium and chloride reabsorption in the proximal and distal tubules. … Ethacrynic acid binds to NKCC2 transporter and inhibits it, preventing Na+, K+ and Cl- reabsorption from the lumen.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Omeprazole Action Pathway
smpdb.ca/view/SMP0122674Drug actionThe bicarbonate ions go into the blood via the chloride anion exchanger on the basolateral membrane which exchanges the hydrogen bicarbonate for Cl- ions. … In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+.
Enzymes: Chloride anion exchanger, Sodium/potassium-transporting ATPase subunit alpha-1Esomeprazole Action Pathway
smpdb.ca/view/SMP0123196Drug actionThe bicarbonate ions go into the blood via the chloride anion exchanger on the basolateral membrane which exchanges the hydrogen bicarbonate for Cl- ions. … In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+.
Enzymes: Chloride anion exchanger, Sodium/potassium-transporting ATPase subunit alpha-1Lansoprazole Action Pathway
smpdb.ca/view/SMP0123261Drug actionThe bicarbonate ions go into the blood via the chloride anion exchanger on the basolateral membrane which exchanges the hydrogen bicarbonate for Cl- ions. … In parietal cells, carbonic anhydrase converts water and carbon dioxide to hydrogen bicarbonate ions and H+.
Enzymes: Chloride anion exchanger, Sodium/potassium-transporting ATPase subunit alpha-1Kidney Function - Distal Convoluted Tubule
smpdb.ca/view/SMP0121012PhysiologicalIn addition, sodium, chlorine, and calcium are also reabsorbed back into the systemic circulation via their respective channels and exchangers. … As a result, a high concentration of sodium, chlorine, and calcium in the blood vessels occurs. The reabsorption of ions and water increases blood fluid volume and blood pressure.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Kidney Function - Ascending Limb of The Loop of Henle
smpdb.ca/view/SMP0121010PhysiologicalChloride, potassium, and sodium are co-transported across the apical membrane (closest to the lumen) via transporters from the filtrate. … In addition, the three ions are transported across the basolateral membrane (closest to the renal interstitium) via other means such as the sodium potassium ATPase transports and the chloride channels
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Amiloride Action Pathway (New)
smpdb.ca/view/SMP0126243Drug actionThis promotes the loss of sodium and water from the body, but without depleting potassium. … potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1Plasma protein fraction (human)
go.drugbank.com/drugs/DB13968ApprovedInvestigational[L2262] The proteins in PPFh are stabilized with sodium caprylate and acetyltryptophan and it contains some electrolytes such as sodium, potassium and chloride.[L2261] … The composition of PPFh should be 5% of protein from which 83% should consist of albumin and no more of 17% should be globulin.
Categories: Amino Acids, Peptides, and ProteinsFurosemide Diuretic Action Pathway
smpdb.ca/view/SMP0122712Drug actionThis is relieves symptoms such as swelling/ edema and hypertension in patients. Furosemide may also inhibit sodium and chloride reabsorption in the proximal and distal tubules. … It binds to this transporter, inhibiting it and preventing Na+, K+ and Cl- reabsorption from the lumen.
Enzymes: Chloride channel protein ClC-Ka, Sodium/potassium-transporting ATPase subunit alpha-1