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Displaying results 891 - 900 of 10000 in total
  1. Target

    Insulin-like growth factor 1 receptor

    go.drugbank.com/bio_entities/BE0000858
    TargetHumans

    JNK kinases can also be activated by the IGF1R. … Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins.

    Synonyms: IGF-I receptor, Insulin-like growth factor I receptor
  2. Target

    DNA-binding transcriptional regulator NtrC

    go.drugbank.com/bio_entities/BE0001282
    TargetSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

    Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open p...

    Synonyms: Nitrogen regulator I, Nitrogen regulation protein NR(I)
  3. Target

    Apolipoprotein L1

    go.drugbank.com/bio_entities/BE0009069
    TargetHumans

    May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. A component of trypanosome lytic factor of human serum; plays a crucial role in kil...

    Synonyms: ApoL-I, Apolipoprotein L-I
  4. Target

    Geranylgeranyl transferase type-1 subunit beta

    go.drugbank.com/bio_entities/BE0001142
    TargetHumans

    Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Known substrates include...

    Synonyms: GGTase-I-beta, Geranylgeranyl transferase type I subunit beta
  5. Target

    Cysteine dioxygenase type 1

    go.drugbank.com/bio_entities/BE0000569
    TargetEnzymeHumans

    Rate-limiting enzyme of the cysteine catabolic process to taurine, which catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen

    Synonyms: CDO-I, Cysteine dioxygenase type I
  6. Drug

    Butylscopolamine

    go.drugbank.com/drugs/DB09300
    ApprovedInvestigationalVet approved

    It is not a pain medication in the normal sense, since it does not directly affect pain, but rather works to prevent painful cramps and spasms from occurring. … It is used to treat pain and discomfort caused by abdominal cramps, menstrual cramps, or other spasmodic activity in the digestive system. It is also effective at preventing bladder spasms.

    Mixtures: DOLORSIN® FEM CAPSULA DURA CON CONTENIDO LIQUIDO, BIPASMIN COMPUESTO NSynonyms: N-butylscopolammonium, N-butylscopolammonium ion
  7. Drug

    Montelukast

    go.drugbank.com/drugs/DB00471
    ApprovedInvestigational

    Montelukast was first approved for clinical use by the US FDA in 1998 as Merck's brand name Singulair. … worldwide via millions of prescriptions annually and has since become available as a generic and as a brand name product.

    Mixtures: BROCRIPTIN® 10 MG/ 5 MG, GLEMONT L® TABLETAS RECUBIERTASCategories: Agents to Treat Airway Disease, Cytochrome P-450 Substrates
  8. Drug

    Dipropylene glycol

    go.drugbank.com/drugs/DB14140
    Investigational

    Synonyms: 4-Oxa-2,6-heptandiol, 1,1'-Oxybis(2-propanol)Products: Abelia pomegranate bounce up mask, Dr.g A-clear Balancing Moisturizer
  9. Drug

    Kappadione

    go.drugbank.com/drugs/DB09332
    Approved

    Kappadione is a Vitamin K derivative (chemically, it is menadiol sodium diphosphate), previously approved by FDA prior to 1982 and marketed by Lilly Marketing for this drug has been discontinued and is … not available in North America [L1543].

  10. Indication

    Non-Hodgkin's Lymphoma (NHL)

    go.drugbank.com/conditions/DBCOND0030854
    Drugs: Bleomycin · Chlorambucil · Cladribine · Cyclophosphamide · Cytarabine · Daunorubicin +8 more
    Synonyms: Non-Hodgkin lymphoma, no ICD-O subtype, Non-Hodgkin lymphoma, no ICD-O subtype (morphologic abnormality)