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Displaying results 911 - 920 of 10000 in total
  1. Pathway

    Pindolol B2-Adrenergic Vasodilation Action Pathway

    smpdb.ca/view/SMP0126653
    Drug action

    Pindolol is a beta adrenoceptor antagonist and partial agonist used to treat hypertension, edema, ventricular tachycardias, and atrial fibrillation. It can be found under the bran names Viskazide and Visken and is administered as an oral...

    Drugs: ATP · Pindolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  2. Pathway

    Acetaminophen Metabolism Pathway

    smpdb.ca/view/SMP0000640
    Drug metabolism

    Acetaminophen (APAP) is metabolized primarily in the liver. Glucuronidation is the main route, accounting for 45-55% of APAP metabolism, and is mediatied by UGT1A1, UGT1A6, UGT1A9, UGT2B15 in the liver and UGT1A10 in the gut. APAP can al...

    Drugs: Glutathione · NADH · ATP · Acetaminophen · Mesoheme · Uridine-5'-Diphosphate
    Enzymes: Glutathione S-transferase P, Glutathione S-transferase theta-1
  3. Pathway

    Ranitidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0122729
    Drug action

    Ranitidine is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epith...

    Drugs: ATP · Ranitidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  4. Pathway

    Cimetidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0123152
    Drug action

    Cimetidine is an H2 receptor antagonist drug that is mainly used to treat peptic ulcers and heartburns. It works by acting as a competitive inhibitor and blocks the action of histamine on Histamine H2 receptors. This ultimately reduces g...

    Drugs: ATP · Cimetidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  5. Pathway

    Metiamide H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0123167
    Drug action

    Metiamide is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epithe...

    Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Metiamide
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  6. Pathway

    Roxatidine Acetate H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0123168
    Drug action

    Roxatidine Acetate is an histamine H2 receptor antagonist used to treat stomach ulcers and Gastroesophageal Reflux Disease (GERD). After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stoma...

    Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Roxatidine acetate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  7. Pathway

    Nizatidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0126776
    Drug action

    Nizatidine is an H2 Histamine receptor antagonist used to treat acid reflux disorders and a variety of ulcers. Nizatidine is taken orally as a solution or a capsule. Once it is transported to gastric basolateral membrane of parietal cell...

    Drugs: ATP · Nizatidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  8. Pathway

    Lavoltidine H2 Anti-histamine Action Pathway

    smpdb.ca/view/SMP0126790
    Drug action

    Lavoltidine has been used in trials studying the diagnostic of Reflux, Gastroesophageal and Gastroesophageal Reflux Disease. After being taken orally, it is absorbed in the GI tract and travels through the blood to get to the stomach epi...

    Drugs: ATP · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate · Lavoltidine
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  9. Pathway

    Famotidine H2 Anti-Histamine Action Pathway

    smpdb.ca/view/SMP0126789
    Drug action

    Famotidine is a histamine H2 receptor antagonist used to treat gastroesophageal reflux disease and various ulcers. Famotidine displays high selectivity towards H2 histamine receptors compared to other H2 anti-histamines. After being take...

    Drugs: ATP · Famotidine · Potassium cation · Magnesium cation · Zinc · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
  10. Drug

    Oxantel

    go.drugbank.com/drugs/DB13670
    Investigational

    Oxantel is an anthelmintic drug that targets parasitic acetylcholine receptors.[A275093, A275098]

    Mixtures: VANPAR®, PIRAXTEL® SUSPENSIONCategories: Heterocyclic Compounds, 1-Ring