Search
Potassium voltage-gated channel subfamily A member 2
go.drugbank.com/bio_entities/BE0004715TargetHumansIn contrast, a heteromultimer formed by KCNA2 and KCNA4 shows rapid inactivation (PubMed:8495559). … Plays a role in the regulation of the time spent in non-rapid eye movement (NREM) sleep (By similarity)
Polypeptides: Potassium voltage-gated channel subfamily A member 2Potassium voltage-gated channel subfamily A member 3
go.drugbank.com/bio_entities/BE0004716TargetHumansAssuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with
Polypeptides: Potassium voltage-gated channel subfamily A member 3Potassium voltage-gated channel subfamily A member 5
go.drugbank.com/bio_entities/BE0004717TargetHumansMay play a role in regulating the secretion of insulin in normal pancreatic islets … Required for normal electrical conduction including formation of the infranodal ventricular conduction system and normal action potential configuration, as a result of its interaction with XIRP2 (By similarity
Polypeptides: Potassium voltage-gated channel subfamily A member 5Potassium voltage-gated channel subfamily A member 6
go.drugbank.com/bio_entities/BE0004718TargetHumansVoltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient (Pu...
Polypeptides: Potassium voltage-gated channel subfamily A member 6Potassium voltage-gated channel subfamily A member 10
go.drugbank.com/bio_entities/BE0004720TargetHumansVoltage-gated potassium ion channel that mediates K(+) permeability of excitable membranes. When opened in response to the voltage difference across the membrane, KCNA10 channel selectively allows the flow of potassium ions across the me...
Polypeptides: Potassium voltage-gated channel subfamily A member 10A disintegrin and metalloproteinase with thrombospondin motifs 13
go.drugbank.com/bio_entities/BE0009336EnzymeTargetHumansCleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 13C-type lectin domain family 12 member A
go.drugbank.com/bio_entities/BE0010945TargetHumansAlso recognizes dead cells by acting as a receptor for monosodium urate crystals, leading to down-regulate neutrophil activation (PubMed:38367667, PubMed:38386511). … Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid (PubMed:31269448, PubMed:36542980).
Polypeptides: C-type lectin domain family 12 member A2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
go.drugbank.com/bio_entities/BE0000518TargetHumansPyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA
Polypeptides: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialA disintegrin and metalloproteinase with thrombospondin motifs 5
go.drugbank.com/bio_entities/BE0003730TargetHumansPlays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties.
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 5Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 11Pantoprazole
go.drugbank.com/drugs/DB00213ApprovedInvestigational[A177577, A177580] Pantoprazole doses should be slowly lowered, or tapered, before discontinuing as rapid discontinuation of PPIs such as pantoprazole may cause a rebound effect and a short term increase … [FDA Label] Due to their good safety profile and as several PPIs are available over the counter without a prescription, their current use in North America is widespread.
Mixtures: OCAM® DUO.Categories: Cytochrome P-450 Substrates, P-glycoprotein inhibitors