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A disintegrin and metalloproteinase with thrombospondin motifs 13
go.drugbank.com/bio_entities/BE0009336EnzymeTargetHumansCleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 13C-type lectin domain family 12 member A
go.drugbank.com/bio_entities/BE0010945TargetHumansAlso recognizes dead cells by acting as a receptor for monosodium urate crystals, leading to down-regulate neutrophil activation (PubMed:38367667, PubMed:38386511). … Also acts as a pattern-recognition receptor for pathogen-associated molecules, such as plasmodium hemozoin or mycobacterial micolic acid (PubMed:31269448, PubMed:36542980).
Polypeptides: C-type lectin domain family 12 member A2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
go.drugbank.com/bio_entities/BE0000518TargetHumansPyridoxal phosphate (PLP) dependent enzyme, which catalyzes the cleavage of 2-amino-3-oxobutanoate to glycine and acetyl-CoA
Polypeptides: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrialA disintegrin and metalloproteinase with thrombospondin motifs 5
go.drugbank.com/bio_entities/BE0003730TargetHumansPlays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its VCAN remodeling properties.
Polypeptides: A disintegrin and metalloproteinase with thrombospondin motifs 5Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 11Docusate
go.drugbank.com/drugs/DB11089ApprovedDocusate, or dioctyl sulfosuccinate, is a stool softener indicated for the treatment of constipation[A32201]. … Additionally, it does not appear to lessen symptoms associated with constipation such as abdominal cramps. Still docusate is available in over-the-counter products as a common laxative.
Mixtures: EX-lax Light Formula Lax W Stool Soften Tab, Natalvirt CaProducts: Lax-A Soft, Pedia-LaxTigecycline
go.drugbank.com/drugs/DB00560ApprovedInvestigationalTigecycline is a glycylcycline antibiotic developed and marketed by Wyeth under the brand name Tygacil. … It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus. It was granted fast-track approval by the U.S.
Synonyms: (4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamideProducts: TIGECLIN ® POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE., TIGEVITAE® 50 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLEPotassium voltage-gated channel subfamily A member 1
go.drugbank.com/bio_entities/BE0000781TargetHumansRegulates the frequency of neuronal action potential firing in response to mechanical stimuli, and plays a role in the perception of pain caused by mechanical stimuli, but does not play a role in the perception … In contrast, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed:17156368).
Polypeptides: Potassium voltage-gated channel subfamily A member 1HLA class I histocompatibility antigen, A alpha chain
go.drugbank.com/bio_entities/BE0003483TargetHumansIn complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive
Polypeptides: HLA class I histocompatibility antigen, A alpha chainSynonyms: HLA-A, MHC class I antigen A*3Potassium voltage-gated channel subfamily A member 7
go.drugbank.com/bio_entities/BE0004719TargetHumansAssuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with
Polypeptides: Potassium voltage-gated channel subfamily A member 7C-type lectin domain family 14 member A
go.drugbank.com/bio_entities/BE0005467TargetHumansPolypeptides: C-type lectin domain family 14 member A