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Methohexital
go.drugbank.com/drugs/DB00474ApprovedAn intravenous anesthetic with a short duration of action that may be used for induction of anesthesia.
Synonyms: (±)-5-allyl-1-methyl-5-(1-methyl-2-pentynyl)barbituric acid, 5-Allyl-5-(3-hexyn-2-yl)-1-methylbarbituric acidCategories: Heterocyclic Compounds, 1-RingTalbutal
go.drugbank.com/drugs/DB00306ApprovedIllicitTalbutal, also called 5-allyl-5-sec-butylbarbituric acid, is a barbiturate with a short to intermediate duration of action. Talbutal is a schedule III drug in the U.S.
Categories: Heterocyclic Compounds, 1-RingSynonyms: (RS)-5-allyl-5-sec-butylpyrimidine-2,4,6(1H,3H,5H)-trione, 5-allyl-5-sec-butylbarbituric acidArsenate Detoxification
smpdb.ca/view/SMP0121123MetabolicFrom here, it forms methylarsonite via the glutathione S-transferase omega-1 enzyme again. … The methylarsonite reacts with S-adenosylmethionine, catalyzed by arsenite methyltransferase, in order to become dimethylarsinate.
Enzymes: Glutathione S-transferase omega-1Gq Serotonergic Smooth Muscle Contraction
smpdb.ca/view/SMP0126954PhysiologicalAlthough numerous GPCRs have the ability to couple to more than one heterotrimeric G protein, a given GPCR is typically classified based on the G protein subfamily (e.g., Gs, Gi/o, or Gq/11) it preferentially activates. Signaling via Gq-...
Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2Sumatriptan
go.drugbank.com/drugs/DB00669ApprovedInvestigational[L6793,L6796,L6799,L6805,L6808,L6811] Sumatriptan is the first of the triptans and was made available in Europe in 1991 to treat migraines. … Sumatriptan is a serotonin receptor agonist commonly used to treat migraines and sometimes cluster headaches.
Mixtures: TRASS® TABLETA RECUBIERTA, TRASS® TABLETA RECUBIERTACategories: P-glycoprotein substrates, Heterocyclic Compounds, 2-RingLysophosphatidic Acid LPA6 Signalling
smpdb.ca/view/SMP0063759SignalingLysophosphatidic acid (LPA) is a water-soluble phospholipid derivative and a potent signalling molecule that binds to six known lysophosphatidic acid receptors (LPARs), named LPA1-LPA6. All six receptors belong to the G protein-coupled r...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLasCyclopentamine
go.drugbank.com/drugs/DB08999ApprovedWithdrawnCyclopentamine is a sympathomimetic alkylamine, classified as a vasoconstrictor. Cyclopentamine was an over the counter treatment for nasal congestion in Europe and Australia. … It has been widely discontinued due to the safety, effectiveness, and availability of a similar drug, propylhexedrine.
Muscular Gs Protein Cascade
smpdb.ca/view/SMP0126976PhysiologicalG proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in transmitting signals from a variety of stimuli outside a cell to its interior. Their...
Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1Maralixibat
go.drugbank.com/drugs/DB16226ApprovedInvestigationalUse (CHMP) recommended maralixibat be granted marketing authorization for the treatment of cholestatic pruritus in patients with Alagille syndrome:[L43547] it was granted marketing authorization in Europe … Maralixibat (also known as SHP625, LUM001, and lopixibat) is an ileal bile acid transporter inhibitor, like [odevixibat].
Categories: Cytochrome P-450 CYP3A Inhibitors, Heterocyclic Compounds, 2-RingSecnidazole
go.drugbank.com/drugs/DB12834ApprovedInvestigational[A245503] Secnidazole has been available in many other countries in Europe, Asia, South America, and Africa for decades. … Secnidazole is a second-generation 5-nitroimidazole antimicrobial agent.
Synonyms: 1-(2-methyl-5-nitro-1H-imidazol-1-yl) propan-2 ol, 1-(2 hydroxypropyl)-2-methyl-5-nitroimidazoleMixtures: FUNEX® - S TABLETA, BATEN ® S TABLETAS RECUBIERTAS