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Displaying results 941 - 950 of 10000 in total
  1. Pathway

    Dipivefrin B2-Adrenergic Ciliary Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126568
    Drug action

    Dipivefrin is a prodrug of epinephrine used in ophthalmic solutions to reduce intraocular pressure in chronic open-angle glaucoma. It is available as ophthalmic solution (eye drops). Dipivefrin is a prodrug with little or no pharmacologi...

    Drugs: ATP · Dipivefrin · Epinephrine · Potassium cation · Calcium · Magnesium cation +1 more
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  2. Pathway

    Propranolol B2-Adrenergic Vasoconstriction Action Pathway

    smpdb.ca/view/SMP0126650
    Drug action

    Organization's List of Essential Medicines and a prototypical drug of its class, propranolol is a non-cardioselective beta blocker and it is typically synthesized as a racemic mixture of 2 enantiomers where the S(

    Drugs: ATP · Propranolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  3. Pathway

    Lysophosphatidic Acid LPA4 Signalling

    smpdb.ca/view/SMP0063756
    Signaling

    The Gα12/13 subunit regulates cell motility and cytoskeletal remodelling by activating the Rho/ROCK and Rho/SRF pathways. … LPA4-mediated adhesion seems to oppose LPA1/LPA2-mediated cell motility. This receptor can couple with the G proteins Gαs, Gαi/o, Gαq/11, and Gα12/13.

    Drugs: ATP · Calcium · Magnesium cation · Cyclic adenosine monophosphate · Pyrophosphoric acid
    Enzymes: Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
  4. Pathway

    Carteolol B2-Adrenergic Ciliary Muscle Contraction Action Pathway

    smpdb.ca/view/SMP0126201
    Drug action

    Carteolol is a beta adrenergic antagonist used to treat arrhythmia, angina, hypertension, and glaucoma. For the treatment of intraocular hypertension and chronic open-angle glaucoma. Carteolol is a beta1 and beta2 (non-selective) adrener...

    Drugs: ATP · Carteolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  5. Pathway

    Droxidopa B2-Adrenergic Artery Dilation Action Pathway

    smpdb.ca/view/SMP0126493
    Drug action

    Droxidopa is a medication used to treat symptomatic neurogenic orthostatic hypotension (nOH) caused by dopamine beta-hydroxylase deficiency, non-diabetic autonomic neuropathy and primary autonomic failure caused by conditions such as Par...

    Drugs: ATP · Norepinephrine · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  6. Pathway

    Norepinephrine B2-Adrenergic Artery Dilation Action Pathway

    smpdb.ca/view/SMP0126573
    Drug action

    Norepinephrine is a sympathomimetic used in the control of blood pressure during various hypotensive states and as an adjunct treatment during cardiac arrest. It can be found under the brand name Levophed. Precursor of epinephrine that i...

    Drugs: ATP · Norepinephrine · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  7. Pathway

    Carteolol B1-Adrenergic Ciliary Muscle Contraction Action Pathway

    smpdb.ca/view/SMP0126647
    Drug action

    By antagonizing the beta-1 adrenergic receptor and blocking G(s) signalling, smooth muscle constriction of the ciliary muscles of the eye make it more difficult for the aqueous humour to reach the eye.

    Drugs: ATP · Carteolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  8. Pathway

    Nadolol B2-Adrenergic Vasoconstriction Action Pathway

    smpdb.ca/view/SMP0126648
    Drug action

    Nadolol is a non-selective beta blocker. It can be administered orally, where it passes through hepatic portal circulation, and enters the bloodstream and travels to act on cardiomyocytes. In bronchial and vascular smooth muscle, nadolol...

    Drugs: ATP · Nadolol · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  9. Pathway

    Gs Adrenergic Smooth Muscle Relaxation

    smpdb.ca/view/SMP0126934
    Physiological

    The mechanism of adrenoreceptors. Adrenaline or noradrenaline are receptor ligands to either α1, α2 or β-adrenoreceptors. The β receptor couples to Gs and increases intracellular cAMP activity, resulting in e.g. heart muscle contraction,...

    Drugs: ATP · Potassium cation · Calcium · Magnesium cation · Cyclic adenosine monophosphate
    Enzymes: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
  10. Drug

    Butabarbital

    go.drugbank.com/drugs/DB00237
    ApprovedIllicitWithdrawn

    Butabarbital, or Butisol, is a fast onset barbiturate with short duration of action compared to other barbiturates. … [A201977,L13613] Butabarbital is less commonly used in recent years, as more patients are typically prescribed benzodiazepines.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-ethyl-5-(1-methylpropyl)barbituric acid, 5-ethyl-5-(1-methylpropyl)-2,4,6(1H,3H,5H)-pyrimidinetrione