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Displaying results 941 - 950 of 10000 in total
  1. Target

    2-amino-3-ketobutyrate coenzyme A ligase

    go.drugbank.com/bio_entities/BE0002049
    TargetEscherichia coli (strain K12)

    Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.

    Polypeptides: 2-amino-3-ketobutyrate coenzyme A ligase
  2. Target

    2,5-diketo-D-gluconic acid reductase A

    go.drugbank.com/bio_entities/BE0002618
    TargetCorynebacterium sp. (strain ATCC 31090)

    Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates. 25DKGR-A exhibits a greater selectivity

    Polypeptides: 2,5-diketo-D-gluconic acid reductase ASynonyms: 2,5-DKG reductase A
  3. Target

    A-type voltage-gated potassium channel KCND2

    go.drugbank.com/bio_entities/BE0003603
    TargetHumans

    In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes. … Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity).

    Polypeptides: A-type voltage-gated potassium channel KCND2Function: A-type (transient outward) potassium channel activity
  4. Target

    A-type voltage-gated potassium channel KCND3

    go.drugbank.com/bio_entities/BE0003604
    TargetHumans

    In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). … Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (PubMed:10200233, PubMed:17187064, PubMed

    Polypeptides: A-type voltage-gated potassium channel KCND3Function: A-type (transient outward) potassium channel activity
  5. Target

    A-type voltage-gated potassium channel KCND1

    go.drugbank.com/bio_entities/BE0004726
    TargetHumans

    Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative … Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons.

    Polypeptides: A-type voltage-gated potassium channel KCND1Function: A-type (transient outward) potassium channel activity
  6. Target

    cAMP-dependent protein kinase (Protein kinase A)

    go.drugbank.com/bio_entities/BE0010127
    TargetHumans

    Phosphorylates a large number of substrates in the cytoplasm and the nucleus … Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131)

  7. Drug

    Acetylcysteine

    go.drugbank.com/drugs/DB06151
    ApprovedInvestigational

    [L31378,L31383,L31388,L31478] Acetylcysteine has also been studied for a wide variety of off-label indications with mixed results. … Acetylcysteine is an antioxidant and glutathione inducer indicated for mucolytic therapy and the treatment of [acetaminophen] overdose.

    Mixtures: N-ACETILCISTEÍNA 2 G + GUAYACOLATO DE GLICERILO 2 G JARABE, AMINOPLASMAL-5% E INFUSIONCategories: Compounds used in a research, industrial, or household setting
  8. Drug

    Cephalexin

    go.drugbank.com/drugs/DB00567
    ApprovedInvestigationalVet approved

    [A179071,A179074] This antibiotic contains a beta lactam and a dihydrothiazide. … [A179071] Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis.[A179083,L6547] Cephalexin was approved by the FDA on 4 January 1971.

    Synonyms: (6R,7R)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-beta-(D-alpha-Amino-alpha-phenylacetylamino)-3-methyl-3-cephem-4-carboxylic acidInternational brands: L-Keflex
  9. Target

    V-type proton ATPase catalytic subunit A

    go.drugbank.com/bio_entities/BE0003569
    TargetHumans

    Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates … May play a role in neurite development and synaptic connectivity (PubMed:29668857)

    Polypeptides: V-type proton ATPase catalytic subunit ASynonyms: V-ATPase subunit A
  10. Target

    Nuclear receptor subfamily 4immunitygroup A member 1

    go.drugbank.com/bio_entities/BE0010494
    TargetHumans

    Plays a role in the vascular response to injury (By similarity)

    Polypeptides: Nuclear receptor subfamily 4immunitygroup A member 1