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High molecular weight rhoptry protein 2
go.drugbank.com/bio_entities/BE0009195TargetPlasmodium falciparum (isolate 3D7)Participates in the formation of new permeability pathways in Plasmodium-infected erythrocytes enabling the uptake of nutrients from the blood plasma (PubMed:28252383). Required for maintaining invasion capacity of merozoites (PubMed:282...
Polypeptides: High molecular weight rhoptry protein 245 kDa immediate-early protein 2
go.drugbank.com/bio_entities/BE0009327TargetHuman cytomegalovirus (strain Towne)Activates the E1.7 promoter. This activation is augmented by the IE1 protein. It down-regulates the transcription of genes under the control of the major IE promoter.
Polypeptides: 45 kDa immediate-early protein 2Serine/threonine-protein kinase PAK 2
go.drugbank.com/bio_entities/BE0009506TargetHumansSerine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed...
Polypeptides: Serine/threonine-protein kinase PAK 2Synonyms: PAK-2, p21-activated kinase 2NAD-dependent protein deacetylase sirtuin-2
go.drugbank.com/bio_entities/BE0009759TargetHumansFunctions in the antephase checkpoint preventing precocious mitotic entry in response to microtubule stress agents, and hence allowing proper inheritance of chromosomes (PubMed:12697818, PubMed:16909107
Polypeptides: NAD-dependent protein deacetylase sirtuin-2Synonyms: SIR2-like protein 2, Regulatory protein SIR2 homolog 2Solute carrier family 23 member 2
go.drugbank.com/bio_entities/BE0009869TransporterTargetHumansMediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate (PubMed:10471399)
Polypeptides: Solute carrier family 23 member 2Synonyms: Na(+)/L-ascorbic acid transporter 2, Yolk sac permease-like molecule 2Programmed cell death 1 ligand 2
go.drugbank.com/bio_entities/BE0010315TargetHumansPlays a critical role in induction and maintenance of immune tolerance to self (PubMed:11224527, PubMed:12538684). Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progressio...
Polypeptides: Programmed cell death 1 ligand 2Synonyms: PD-1 ligand 2, PDCD1 ligand 2Nuclear cap-binding protein subunit 2
go.drugbank.com/bio_entities/BE0013483TargetHumansa 5' to 3' direction through the nuclear pore. … Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated
Polypeptides: Nuclear cap-binding protein subunit 2Neurogenic locus notch homolog protein 2
go.drugbank.com/bio_entities/BE0013939TargetHumansFunctions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination.
Polypeptides: Neurogenic locus notch homolog protein 2Synonyms: Notch 2Membrane-bound glycerophospholipid O-acyltransferase 2
go.drugbank.com/bio_entities/BE0015719EnzymeHumansAcyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophospholipid leading to the production of a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known a...
Polypeptides: Membrane-bound glycerophospholipid O-acyltransferase 2Synonyms: LPLAT 2, Lysophospholipid acyltransferase 2Taste receptor type 2 member 3
go.drugbank.com/bio_entities/BE0023234TargetHumansGustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5
Polypeptides: Taste receptor type 2 member 3