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Methyclothiazide
go.drugbank.com/drugs/DB00232ApprovedWithdrawnA thiazide diuretic with properties similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p825)
Categories: Heterocyclic Compounds, 2-RingTyrosinemia Type 1
go.drugbank.com/conditions/DBCOND0091509Drugs: NitisinoneSynonyms: FAH-gene related tyrosinemia type 1, FAH-gene related tyrosinaemia type 1G protein-coupled receptor kinase 2
go.drugbank.com/bio_entities/BE0000341TargetHumansSuch receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:14976224, PubMed:16179383, PubMed:19306925, PubMed … Also able to mediate phosphorylation-independent desensitization of dopamine receptor DRD2 (By similarity)
Polypeptides: G protein-coupled receptor kinase 2Synonyms: Beta-adrenergic receptor kinase 1Receptor tyrosine-protein kinase erbB-2
go.drugbank.com/bio_entities/BE0000511TargetEnzymeHumansEssential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. … Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding.
Polypeptides: Receptor tyrosine-protein kinase erbB-2Synonyms: Metastatic lymph node gene 19 protein, Tyrosine kinase-type cell surface receptor HER2Taste receptor type 1 member 3
go.drugbank.com/bio_entities/BE0000582TargetHumansFunctions as a G protein-coupled receptor and primarily signals through the gustducin heterotrimer (PubMed:40339580). … The sweet taste receptor has lower affinity for natural sugars than for synthetic sweeteners (PubMed:40339580, PubMed:40555359).
Polypeptides: Taste receptor type 1 member 3Synonyms: Sweet taste receptor T1R3Insulin-like growth factor 1 receptor
go.drugbank.com/bio_entities/BE0000858TargetHumansLigand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor … The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
Polypeptides: Insulin-like growth factor 1 receptorSynonyms: IGF-I receptor, Insulin-like growth factor I receptorC-C chemokine receptor type 5
go.drugbank.com/bio_entities/BE0000911TargetHumansParticipates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed:30713770) … Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.
Polypeptides: C-C chemokine receptor type 5Growth factor receptor-bound protein 2
go.drugbank.com/bio_entities/BE0000917TargetHumansNon-enzymatic adapter protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular responses, including signaling transduction and gene expression … Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells (PubMed:36864087, PubMed:9489702).
Polypeptides: Growth factor receptor-bound protein 2Function: ephrin receptor bindingHigh affinity nerve growth factor receptor
go.drugbank.com/bio_entities/BE0001039TargetHumansReceptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and … High affinity receptor for NGF which is its primary ligand (PubMed:1281417, PubMed:15488758, PubMed:17196528, PubMed:1849459, PubMed:1850821, PubMed:22649032, PubMed:27445338, PubMed:8325889).
Polypeptides: High affinity nerve growth factor receptorSynonyms: Tyrosine kinase receptor, Tyrosine kinase receptor ANeuronal acetylcholine receptor subunit alpha-9
go.drugbank.com/bio_entities/BE0002343TargetHumansComponent of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collecti...
Polypeptides: Neuronal acetylcholine receptor subunit alpha-9Synonyms: Nicotinic acetylcholine receptor subunit alpha-9