Receptor tyrosine-protein kinase erbB-2

BE0000511ProteinHumansERBB2

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. It is acted on by 66 drugs in DrugBank.

Gene name
ERBB2
UniProtKB entry
P04626Swiss-Prot
Cellular location
Cell membrane
Residues / weight
1,255 residues · 137,909 Da
Also known as
2.7.10.1 · HER2 · Metastatic lymph node gene 19 protein · MLN 19 · MLN19

Resolves to

Protein
UniProtP04626UniProt nameERBB2_HUMAN
Gene
HGNCHGNC:3430NCBI Gene2064GenBank553282GeneCardsERBB2
Pharmacology
IUPHAR/GtoPdb2019KEGGhsa:2064
Structure
PDB1MFGPDB1MFLPDB1MW4
Drugs

What you can answer from here — as of September 07, 2019

66DrugsApproved to experimental, with action, bond type and pharmacological action
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583Clinical trialsTrials of drugs acting on it, by phase and status
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32GO termsFunction, process and component, as structured annotations
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5Pfam domainsDomain architecture mapped to Pfam families and clans
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233+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Receptor tyrosine-protein kinase erbB-2, how selective are they, and which programs against it are still in active trials?

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