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Displaying results 951 - 960 of 10000 in total
  1. Drug

    Beclomethasone dipropionate

    go.drugbank.com/drugs/DB00394
    ApprovedInvestigational

    [L6871] It is a prodrug of an active metabolite beclomethasone 17-monopropionate (17-BMP)[A179839] which acts on the glucocorticoid receptor to mediates its therapeutic action. … Beclomethasone dipropionate became first available in a pressurized metered-dose inhaler in 1972 and later in a dry powder inhaler and an aqueous nasal spray.

    Synonyms: (11β,16β)-9-chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione, 9-chloro-11β-hydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-dipropionateInternational brands: Clenil-A
  2. Target

    DNA topoisomerase 1

    go.drugbank.com/bio_entities/BE0000971
    TargetEnzymeHumans

    Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification a...

    Synonyms: DNA topoisomerase I
  3. Drug

    Insulin icodec

    go.drugbank.com/drugs/DB16693
    ApprovedInvestigational

    [L51078]The US FDA subsequently approved insulin icodec in March 2026 for use as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. [L56102] … [L50758,A263818] Insulin icodec was approved by Health Canada in March 2024 for the treatment of adult patients with type 1 or 2 diabetes mellitus,[L50758] and was subsequently approved by the EMA in

    Categories: Drugs Used in Diabetes
  4. Drug

    Tirabrutinib

    go.drugbank.com/drugs/DB15227
    Investigational

    Tirabrutinib is under investigation in clinical trial NCT02626026 (Safety and Pharmacokinetics of GS-4059 in Healthy Volunteers and Subjects With Rheumatoid Arthritis (RA)).

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 6-amino-9-[(3R)-1-but-2-ynoylpyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one, ONO-4059 (free base)
  5. Drug

    Elasomeran

    go.drugbank.com/drugs/DB15654
    ApprovedInvestigational

    In clinical trials, there were no differences in the safety profiles between younger and older (65 years of age and older) study participants. … [L39160, L39277] A similar booster dose is also available in the US for patients 18 years of age and older.

    Mixtures: Spikevax Bivalent (original / Omicron Ba.4/5)Synonyms: MRNA-1273 SARS-COV-2
  6. Target

    Immunoglobulin kappa variable 1D-33

    go.drugbank.com/bio_entities/BE0004164
    TargetHumans

    The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation

    Synonyms: Ig kappa chain V-I region AG, Ig kappa chain V-I region Bi
  7. Target

    Carnitine O-palmitoyltransferase 1, muscle isoform

    go.drugbank.com/bio_entities/BE0017721
    TargetHumans

    Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion

    Synonyms: CPT I, Carnitine palmitoyltransferase I-like protein
  8. Drug

    Merbromin

    go.drugbank.com/drugs/DB13392
    Investigational

    It is an organomercuric disodium salt compound and a fluorescein that is available in many countries, except Switzerland, France, Germany, and the United States where the drug was withdrawn from market … due to the possibility of mercury poisoning.

    Categories: Heterocyclic Compounds, 3-RingProducts: MERBROMINA NA
  9. Target

    Activin receptor type-1

    go.drugbank.com/bio_entities/BE0000264
    TargetHumans

    Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (By similarity). … As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B (PubMed:17911401).

    Synonyms: ACTR-I, TSR-I
  10. Drug

    Cefixime

    go.drugbank.com/drugs/DB00671
    ApprovedInvestigational

    [L49293] The beta-lactam ring of cefixime inhibits bacterial cell wall synthesis by binding to the penicillin-binding proteins which will then result in lysis. … [A262894,A263011 ,L49293] Cephalosporins are beta-lactam antibiotics and can be used to treat gram-positive and gram-negative bacterial infections which include conditions such as skin infections, resistant

    Mixtures: MOLCEF PLUS 100/62.5/5 ML ORAL SUSPANSIYON HAZIRLAMAK ICIN KURU TOZ, 100 ML, MOLCEF PLUS 200 MG+62.5/5 ML ORAL SÜSPANSİYON HAZIRLAMAK İÇİN KURU TOZ, 100 MLCategories: Heterocyclic Compounds, 2-Ring