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Displaying results 951 - 960 of 10000 in total
  1. Pathway

    Metabolism and Physiological Effects of N-Acetylproline

    smpdb.ca/view/SMP0126660
    Metabolic

    N-acetylproline in the body can cause kidney damage and contribute to tumorigenesis, L-proline can be obtained from the diet from foods that are high in protein such as meat, fish, and dairy. … In addition to the NAT enzymes and protein-based acetylation, N-acetylation of free proline can also occur.

    Drugs: Proline · N-Acetylproline
  2. Pathway

    Metabolism and Physiological Effects of N-Acetylvaline

    smpdb.ca/view/SMP0126701
    Metabolic

    In addition to the NAT enzymes and protein-based acetylation, N-acetylation of free valine can also occur. … N-acetylglutamine, N-acetylisoleucine, and N-acetylthreonine) can be detected in the urine with individuals with acylase I deficiency, a genetic disorder.

    Drugs: Valine
  3. Pathway

    Metabolism and Physiological Effects of N-Acetylmethionine

    smpdb.ca/view/SMP0126707
    Metabolic

    In addition to the NAT enzymes and protein-based acetylation, N-acetylation of free methionine can also occur. … NatA also exists in a monomeric state and can post-translationally acetylate acidic N-termini residues (D-, E-).

    Drugs: Methionine · N-Acetylmethionine
  4. Pathway

    Metabolism and Physiological Effects of N-Acetylhistidine

    smpdb.ca/view/SMP0126711
    Metabolic

    In addition to the NAT enzymes and protein-based acetylation, N-acetylation of free histidine can also occur. … In particular, N-Acetylhistidine can be biosynthesized from L-histidine and acetyl-CoA by the enzyme histidine N-acetyltransferase (EC 2.3.1.33).

    Drugs: Histidine
  5. Pathway

    Metabolism and Physiological Effects of Beta-Alanine

    smpdb.ca/view/SMP0126732
    Metabolic

    The associated inhibition of GABA transaminase and displacement of GABA from CNS binding sites can also lead to GABAuria (high levels of GABA in the urine) and convulsions. … When present in sufficiently high levels, beta-alanine can act as a neurotoxin, a mitochondrial toxin, and a metabotoxin. A neurotoxin is a compound that damages the brain or nerve tissue.

    Drugs: Ademetionine · Zinc · beta-Alanine · 1-Methylhistidine
  6. Pathway

    Metabolism and Physiological Effects of Indolelactic Acid

    smpdb.ca/view/SMP0126749
    Metabolic

    Indolelactic acid (CAS: 1821-52-9) is a tryptophan metabolite found in human plasma, serum, and urine. … The enzyme involved in indoleacetic acid production remains unknown, however, candidate genes in the genome include pyruvate:ferredoxin oxidoreductases B and C (PorB, CLOSPO_02262; PorC, CLOSPO_03792).

    Drugs: Tryptophan · Indoleacetic acid
  7. Pathway

    Metabolism and Physiological Effects of 1-Methylhistidine

    smpdb.ca/view/SMP0126760
    Metabolic

    Because 1MH is so abundant in skeletal muscle tissues (being found in the main myofibrillar proteins actin and myosin), the urinary concentrations of 1-methylhistidine can be used as a biomarker for skeletal … In addition to the degradation of muscle proteins, the 1-methylhistidine level can be moderately affected by the degradation of intestinal proteins and meat intake. 1-Methylhistidine has been found to

    Drugs: Histidine · Ademetionine · 1-Methylhistidine
  8. Pathway

    Metabolism and Physiological Effects of Vanillic Acid

    smpdb.ca/view/SMP0126881
    Metabolic

    The deletion mutant of this protein can be used in production of natural vanillin by microbial fermentation from ferulic acid at final concentrations and molar yields on an industrial scale. … Vanillic acid is a phenolic acid found in some forms of vanilla and many other plant extracts. It is a flavouring and scent agent that produces a pleasant, creamy odour.

    Drugs: NADH · Vanillic acid
  9. Drug

    Glycopyrronium

    go.drugbank.com/drugs/DB00986
    ApprovedInvestigationalVet approved

    [A233535,A233540] Early research into glycopyrronium use was for its indication as an adjunct therapy in the treatment of peptic ulcers. … gastric secretions;[L33120] as well as reducing cardiac inhibitory reflexes;[L33120] and reducing bronchoconstriction in COPD.

    Mixtures: Ultibro Breezhaler 110/50mcg Inhalation Powder Hard Capsule, Xoterna Breezhaler 110/50mcg Inhalation Powder Hard CapsuleCategories: Alimentary Tract and Metabolism, formoterol and glycopyrronium bromide
  10. Drug

    Pasireotide

    go.drugbank.com/drugs/DB06663
    ApprovedInvestigational

    Pasireotide is a synthetic long-acting cyclic hexapeptide with somatostatin-like activity. It is marketed as a diaspartate salt called Signifor, which is used in the treatment of Cushing's disease.

    Categories: Pituitary and Hypothalamic Hormones and Analogues, Sex Hormones and InsulinsProducts: SIGNIFOR LAR POWDER AND SOLVENT FOR SUSPENSION FOR INJECTION 20MG, Signifor LAR 20mg powder and solvent for suspension for injection