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Displaying results 961 - 970 of 10000 in total
  1. Drug

    Fluticasone propionate

    go.drugbank.com/drugs/DB00588
    ApprovedInvestigational

    Fluticasone propionate is a synthetic glucocorticoid[F4355,F4358][FDA Label]. … These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358][FDA Label]. Fluticasone propionate was first approved in 1990[L5962].

    Mixtures: HOVID CLEFAN-S POWDER FOR INHALATION 50/250MCG, SALMETEROLO E FLUTICASONE SFCategories: Agents to Treat Airway Disease, P-glycoprotein substrates
  2. Drug

    Carvedilol

    go.drugbank.com/drugs/DB01136
    ApprovedInvestigational

    Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. … [L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the

    Mixtures: CARIVALAN 25/5, CARIVALAN 6.25/5Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  3. Target

    Cytochrome P450 2C9

    go.drugbank.com/bio_entities/BE0002793
    TargetEnzymeHumans

    Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). … Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031)

    Synonyms: (S)-limonene 6-monooxygenase, (S)-limonene 7-monooxygenase
  4. Drug

    Hypochlorous acid

    go.drugbank.com/drugs/DB14135
    Investigational

    An oxyacid of chlorine (HClO) containing monovalent chlorine that acts as an oxidizing or reducing agent.

    Mixtures: Ste-medi, K-100Categories: Compounds used in a research, industrial, or household setting
  5. Indication

    Seizure Disorders

    go.drugbank.com/conditions/DBCOND0046733
    Drugs: Ganaxolone · Midazolam
    Synonyms: Seizure disorder(s)
  6. Target

    Methionine synthase

    go.drugbank.com/bio_entities/BE0003310
    TargetThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

    Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.

    Synonyms: 5-methyltetrahydrofolate S-homocysteine methyltransferase
  7. Target

    Protein S100-A2

    go.drugbank.com/bio_entities/BE0003602
    TargetHumans

    May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes. May a...

    Synonyms: Protein S-100L
  8. Target

    Arsenite methyltransferase

    go.drugbank.com/bio_entities/BE0005015
    TargetEnzymeHumans

    Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is redu...

    Synonyms: S-adenosyl-L-methionine:arsenic(III) methyltransferase
  9. Target

    ATP-citrate synthase

    go.drugbank.com/bio_entities/BE0009867
    TargetEnzymeHumans

    Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism

    Synonyms: ATP-citrate (pro-S-)-lyase
  10. Indication

    Parkinson's Disease (PD)

    go.drugbank.com/conditions/DBCOND0053495
    Drugs: Amantadine · Apomorphine · Benserazide · Biperiden · Bornaprine · Bromocriptine +16 more
    Synonyms: Parkinson&Amp;#39;s Disease