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Displaying results 961 - 970 of 3735 in total
  1. Target

    Receptor tyrosine-protein kinase erbB-2

    go.drugbank.com/bio_entities/BE0000511
    TargetEnzymeHumans

    Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. … Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding.

    Polypeptides: Receptor tyrosine-protein kinase erbB-2Synonyms: Tyrosine kinase-type cell surface receptor HER2
  2. Target

    Taste receptor type 1 member 3

    go.drugbank.com/bio_entities/BE0000582
    TargetHumans

    Functions as a G protein-coupled receptor and primarily signals through the gustducin heterotrimer (PubMed:40339580). … The sweet taste receptor has lower affinity for natural sugars than for synthetic sweeteners (PubMed:40339580, PubMed:40555359).

    Polypeptides: Taste receptor type 1 member 3Synonyms: Sweet taste receptor T1R3
  3. Target

    Insulin-like growth factor 1 receptor

    go.drugbank.com/bio_entities/BE0000858
    TargetHumans

    Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor … IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R

    Polypeptides: Insulin-like growth factor 1 receptorSynonyms: IGF-I receptor, Insulin-like growth factor I receptor
  4. Target

    C-C chemokine receptor type 5

    go.drugbank.com/bio_entities/BE0000911
    TargetHumans

    Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor (PubMed:30713770) … Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level.

    Polypeptides: C-C chemokine receptor type 5
  5. Target

    Growth factor receptor-bound protein 2

    go.drugbank.com/bio_entities/BE0000917
    TargetHumans

    Controls signaling complexes at the T-cell antigen receptor to facilitate the activation, differentiation, and function of T-cells (PubMed:36864087, PubMed:9489702). … Functions also a role in B-cell activation by amplifying Ca(2+) mobilization and activation of the ERK MAP kinase pathway upon recruitment to the phosphorylated B-cell antigen receptor (BCR) (PubMed:25413232

    Polypeptides: Growth factor receptor-bound protein 2Function: ephrin receptor binding
  6. Target

    High affinity nerve growth factor receptor

    go.drugbank.com/bio_entities/BE0001039
    TargetHumans

    Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and … High affinity receptor for NGF which is its primary ligand (PubMed:1281417, PubMed:15488758, PubMed:17196528, PubMed:1849459, PubMed:1850821, PubMed:22649032, PubMed:27445338, PubMed:8325889).

    Polypeptides: High affinity nerve growth factor receptorSynonyms: Tyrosine kinase receptor, Tyrosine kinase receptor A
  7. Target

    Neuronal acetylcholine receptor subunit alpha-9

    go.drugbank.com/bio_entities/BE0002343
    TargetHumans

    Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collecti...

    Polypeptides: Neuronal acetylcholine receptor subunit alpha-9Synonyms: Nicotinic acetylcholine receptor subunit alpha-9
  8. Target

    Interleukin-13 receptor subunit alpha-2

    go.drugbank.com/bio_entities/BE0002421
    TargetHumans

    Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation (PubMed:11861389, PubMed:17030238 … Cell surface receptor that plays a role in the regulation of IL-13-mediated responses (PubMed:11861389, PubMed:17030238).

    Polypeptides: Interleukin-13 receptor subunit alpha-2Synonyms: IL-13 receptor subunit alpha-2
  9. Target

    G protein-coupled estrogen receptor 1

    go.drugbank.com/bio_entities/BE0003446
    TargetHumans

    G protein-coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. … Also functions as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation.

    Polypeptides: G protein-coupled estrogen receptor 1Synonyms: Chemoattractant receptor-like 2, IL8-related receptor DRY12
  10. Target

    Low affinity immunoglobulin epsilon Fc receptor

    go.drugbank.com/bio_entities/BE0003465
    TargetHumans

    Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells.

    Polypeptides: Low affinity immunoglobulin epsilon Fc receptorSynonyms: Lymphocyte IgE receptor