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Displaying results 971 - 980 of 7452 in total
  1. Drug

    Rifamycin

    go.drugbank.com/drugs/DB11753
    ApprovedInvestigationalWithdrawn

    All of the derivatives have slight different physicochemical properties when compared to the parent structure. … [L4800] This drug was also sent for review to the EMA in 2015 by Dr. Falk Pharma Gmbh and it was granted a waiver for the tested conditions.[L4801]

    Categories: Antibiotics for Topical Use, Antiinfectives for Systemic Use
  2. Drug

    Indium In-111 chloride

    go.drugbank.com/drugs/DB09490
    Approved

    and for radiolabeling Zevalin (ibritumomab tiuxetan) in preparations used for radioimmunotherapy procedures. … Indium In-111 Chloride is a diagnostic radiopharmaceutical agent intended for radiolabeling OncoScint (satumomab pendetide) or ProstaScint (capromab pendetide) used for _in vivo_ diagnostic imaging procedures

    Mixtures: OCTREOSCAN FOR INJECTION, Kit for the Preparation of Indium In 111 Pentetreotide
  3. Drug

    Neomycin

    go.drugbank.com/drugs/DB00994
    ApprovedInvestigationalVet approved

    [L11985] Neomycin sulfate is the most common form for pharmaceutical preparations; because the compound is a complex, the amount of neomycin in products is measured in units. … [A191529] Neomycin sulfate as monotherapy is available in an oral solution for adjunct use in the treatment of hepatic coma.

    Mixtures: Equaline Antibiotic Plus Pain Relief for Kids, CVS Health All Purpose KitCategories: Antibiotics for Topical Use, Antibacterials for Systemic Use
  4. Drug

    Aclidinium

    go.drugbank.com/drugs/DB08897
    Approved

    Aclidinium is an anticholinergic for the long-term management of chronic obstructive pulmonary disease (COPD).

    Categories: Drugs for Obstructive Airway Diseases
  5. Target

    Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

    go.drugbank.com/bio_entities/BE0000609
    TargetHumans

    Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex in testis (PubMed:14638692). The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cyt...

    Polypeptides: Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
  6. Drug

    Hexylresorcinol

    go.drugbank.com/drugs/DB11254
    Approved

    It can be found in topical applications for minor skin infections and in oral solutions or throat lozenges for pain relief and first aid antiseptic. … The compound may also be used commonly in various commercial cosmetic anti-aging creams while ongoing studies research the possibility of using hexylresorcinol as an anti-cancer therapy - indications all

  7. Drug

    Elexacaftor

    go.drugbank.com/drugs/DB15444
    ApprovedInvestigational

    for the _F508del-CFTR_ gene - this represents approximately 70[A187373]-90%[A187361,A187355] of all CF patients. … [A187361] Elexacaftor, along with [VX-659], was designed to fill the need for an efficacious CF therapy for patients who are heterozygous for _F508del-CFTR_ and a gene that does not produce protein or

  8. Indication

    Chronic Phase Chronic Myeloid Leukemia

    go.drugbank.com/conditions/DBCOND0057382
    Drugs: Asciminib · Bosutinib · Dasatinib · Daunorubicin · Nilotinib · Ponatinib
    Synonyms: Chronic myelogenous leukemia, no International Classification of Diseases for Oncology subtype
  9. Drug

    Mepyramine

    go.drugbank.com/drugs/DB06691
    ApprovedVet approved

    It has been found in over-the-counter combination products for colds and menstrual symptoms, but is considered to be an unapproved prescription medication used for cough, cold, or allergic conditions. … Mepyramine, or pyrilamine, targets the H1 receptor. It is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect.

    Mixtures: Bronchodex Fort-DM SyrCategories: Antihistamines for Systemic Use, Antihistamines for Topical Use
  10. Drug

    Fexinidazole

    go.drugbank.com/drugs/DB12265
    Approved

    all-oral treatment for first and second stage HAT caused by _T. brucei gambiense_. … [A237550] Historical treatment options for meningoencephalitic HAT include [melarsoprol], [eflornithine], and [nifurtimox]/[eflornithine] combination therapy (NECT), though [melarsoprol] is highly toxic