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Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
go.drugbank.com/bio_entities/BE0004551TargetHumansPreferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly ...
Polypeptides: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1Aluminum chloride
go.drugbank.com/drugs/DB11081ApprovedInvestigationalIn antiperspirant products, FDA approves the use of aluminum chloride as an active ingredient up to 15%, calculated on the hexahydrate form, in an aqueous solution nonaerosol dosage form [L2012]. … Aluminum chloride is a chemical compound with the chemical formula AlCl3. When contaminated with iron chloride, it often displays a yellow color compared to the white pure compound.
Categories: Compounds used in a research, industrial, or household settingProducts: Hemox A, Frenna ACHepatitis C Infections
go.drugbank.com/conditions/DBCOND0072126Drugs: Interferon alfaSynonyms: Hep non-A non-B, Hepatitis non-A non-BSomatotropin
go.drugbank.com/drugs/DB00052ApprovedInvestigational[A228183, L31508] Synthesized in a strain of _Escherichia coli_, recombinant HGH is a polypeptide hormone that contains 191 amino acid residues with a molecular weight of 22 kDa. … [A228188] Recombinant growth hormone is available as a subcutaneous injection for children and adults under a wide variety of brand names.
Categories: Cytochrome P-450 CYP1A2 Inducers, P-glycoprotein substratesProducts: SciTropin A Solution for Injection 5 mg/1.5 ml, SciTropin A Solution for Injection 10 mg/1.5 mlPolyethylene glycol
go.drugbank.com/drugs/DB09287ApprovedInvestigationalVet approvedPEGs have a long history of gastroenterology: PEG 3350 is a common over-the-counter osmotic laxative used to relieve occasional constipation. … Polyethylene glycol (PEG) is a synthetic polymer produced via polymerization of ethylene oxide molecules to make joining units of ethylene glycol by an ether linkage.
Mixtures: Gavilyte-N, Gavilyte G TmCategories: Compounds used in a research, industrial, or household setting, P-glycoprotein inhibitorsAmlodipine
go.drugbank.com/drugs/DB00381ApprovedInvestigationalAmlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. … The option for single daily dosing of amlodipine is an attractive feature of this drug [FDA label].
Synonyms: (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate, 3-Ethyl 5-methylester, (±)-2-[(2-aminoethoxy)methyl]-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylateInternational brands: Atecard-AM, Amlodipine 5Intermittent distinct from a patient’s usual seizure pattern, stereotypic episode Epileptic seizure
go.drugbank.com/conditions/DBCOND0120023Drugs: DiazepamSynonyms: Intermittent distinct from a patient’s usual seizure pattern, stereotypic episode Epileptic seizureFosaprepitant
go.drugbank.com/drugs/DB06717ApprovedInvestigationalFosaprepitant is an intravenously administered antiemetic drug. It is a prodrug of Aprepitant.
Categories: Neurokinin-1 Receptor Antagonists, Substance P/Neurokinin-1 Receptor AntagonistProducts: APRITANT IV® 150 MG POLVO LIOFILIZADO PARA RECONSTITUIR A SOLUCION INYECTABLE, PREQUIM-FCytarabine
go.drugbank.com/drugs/DB00987ApprovedInvestigationalA pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. … Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle.
Categories: Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesSynonyms: Ara-C, 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinoneSerine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
go.drugbank.com/bio_entities/BE0003750TargetHumansThe PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit (PubMed:15525651, PubMed:16580887, PubMed … Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex (PubMed:33243860, PubMed:34004147).
Polypeptides: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoformSynonyms: PP2A subunit A isoform R1-alpha, PP2A subunit A isoform PR65-alpha