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Purine nucleoside phosphorylase
go.drugbank.com/bio_entities/BE0003172TargetPlasmodium falciparum (isolate 3D7)Also catalyzes the phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine; MTI is produced by adenosine deaminase (ADA)-mediated breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product
Synonyms: S-methyl-5'-thioinosine phosphorylaseNifedipine
go.drugbank.com/drugs/DB01115ApprovedInvestigationalNifedipine, or BAY a 1040, is a first generation dihydropyridine L-type calcium channel blocker, similar to [nicardipine]. … [A190273] The most popular of the third generation dihydropyridines is [amlodipine].[A190273] Nifedipine was granted FDA approval on 31 December 1981.[L11383]
Mixtures: NIF TEN 50, NIF-TEN CAPSULECategories: P-glycoprotein inducers, P-glycoprotein inhibitorsColistimethate
go.drugbank.com/drugs/DB01111ApprovedInvestigationalVet approvedColistimethate is particularly indicated when the infection is caused by sensitive strains of Pseudomonas aeruginosa. … Colistimethate is an antibiotic that has been shown to have bactericidal activity against aerobic gram-negative microorganisms.
Products: COLIS-TEK, KOLİSTİPOL 4.500.000 IU IM/IV ENJEKSİYON VE İNHALASYONLUK ÇÖZELTİ HAZIRLAMAK İÇİN TOZ VE ÇÖZÜCÜ 1 FLAKON VE 1 AMPULLeukotriene C4 synthase
go.drugbank.com/bio_entities/BE0001117TargetHumansCan also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator
Synonyms: Glutathione S-transferase LTC4Tilmicosin
go.drugbank.com/drugs/DB11471InvestigationalVet approvedTilmicosin is a macrolide antibiotic. It is used in veterinary medicine for the treatment of bovine respiratory disease and ovine respiratory disease associated with _Mannheimia haemolytica_.
Categories: P-glycoprotein substratesProducts: TP-TILMIPHOS 500MG/G POWDER, TP-Mecotil 300 Sol Tilmicosin Phosphate 300mg/ml SolutionFluticasone propionate
go.drugbank.com/drugs/DB00588ApprovedInvestigationalFluticasone propionate is a synthetic glucocorticoid[F4355,F4358][FDA Label]. … These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications[F4355,F4358][FDA Label]. Fluticasone propionate was first approved in 1990[L5962].
Mixtures: HOVID CLEFAN-S POWDER FOR INHALATION 50/250MCG, SALMETEROLO E FLUTICASONE SFCategories: Agents to Treat Airway Disease, P-glycoprotein substratesCarvedilol
go.drugbank.com/drugs/DB01136ApprovedInvestigationalCarvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker. … [L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the
Synonyms: (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanolMixtures: CARIVALAN 25/5, CARIVALAN 6.25/5Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
go.drugbank.com/bio_entities/BE0001402TargetVACVDisplays methyltransferase, positive regulation of the poly(A) polymerase and transcription elongation activities. Involved in the modification of both mRNA ends and in intermediate and late gene positive transcription elongation. At the...
Synonyms: PAP-SUroporphyrinogen-III C-methyltransferase
go.drugbank.com/bio_entities/BE0002528TargetPseudomonas denitrificansCatalyzes the two successive C-2 and C-7 methylation reactions involved in the conversion of uroporphyrinogen III to precorrin-2 via the intermediate formation of precorrin-1. It is a step in the biosynthesis of both cobalamin (vitamin B...
Synonyms: S-adenosyl-L-methionine:uroporphyrinogen III methyltransferaseHypochlorous acid
go.drugbank.com/drugs/DB14135InvestigationalAn oxyacid of chlorine (HClO) containing monovalent chlorine that acts as an oxidizing or reducing agent.
Synonyms: Chlor(I)-säureMixtures: Ste-medi, K-100