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Displaying results 981 - 990 of 10000 in total
  1. Target

    Retinoic acid receptor RXR-alpha

    go.drugbank.com/bio_entities/BE0000412
    TargetHumans

    Receptor for retinoic acid that acts as a transcription factor (PubMed:10874028, PubMed:11162439, PubMed:11915042, PubMed:37478846).

    Polypeptides: Retinoic acid receptor RXR-alphaSynonyms: Retinoid X receptor alpha, Nuclear receptor subfamily 2 group B member 1
  2. Target

    Interleukin-11 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0000416
    TargetHumans

    Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission.

    Polypeptides: Interleukin-11 receptor subunit alphaSynonyms: IL-11 receptor subunit alpha
  3. Target

    Glutamate receptor ionotropic, NMDA 2B

    go.drugbank.com/bio_entities/BE0000417
    TargetHumans

    Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity)

    Polypeptides: Glutamate receptor ionotropic, NMDA 2BSynonyms: N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3
  4. Target

    Glycine receptor subunit alpha-1

    go.drugbank.com/bio_entities/BE0000433
    TargetHumans

    Subunit of heteromeric glycine-gated chloride channels (PubMed:14551753, PubMed:23994010, PubMed:25730860, PubMed:37821459). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contri...

    Polypeptides: Glycine receptor subunit alpha-1Synonyms: Glycine receptor 48 kDa subunit, Glycine receptor strychnine-binding subunit
  5. Target

    Glutamate receptor ionotropic, NMDA 3B

    go.drugbank.com/bio_entities/BE0000534
    TargetHumans

    Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits. … GluN3B subunit also binds D-serine and, in the absence of glycine, activates glycinergic receptor complexes, but with lower efficacy than glycine (By similarity).

    Polypeptides: Glutamate receptor ionotropic, NMDA 3BSynonyms: N-methyl-D-aspartate receptor subtype 3B
  6. Target

    Interleukin-2 receptor subunit alpha

    go.drugbank.com/bio_entities/BE0000658
    TargetHumans

    Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity.

    Polypeptides: Interleukin-2 receptor subunit alphaSynonyms: IL-2 receptor subunit alpha
  7. Target

    Interferon alpha/beta receptor 1

    go.drugbank.com/bio_entities/BE0000661
    TargetHumans

    Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461 … Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity)

    Polypeptides: Interferon alpha/beta receptor 1Synonyms: IFN-alpha/beta receptor 1, Type I interferon receptor 1
  8. Target

    Retinoic acid receptor RXR-gamma

    go.drugbank.com/bio_entities/BE0000707
    TargetHumans

    Receptor for retinoic acid.

    Polypeptides: Retinoic acid receptor RXR-gammaSynonyms: Retinoid X receptor gamma, Nuclear receptor subfamily 2 group B member 3
  9. Target

    Glycine receptor subunit alpha-2

    go.drugbank.com/bio_entities/BE0000745
    TargetHumans

    Subunit of heteromeric glycine-gated chloride channels (PubMed:15302677, PubMed:16144831, PubMed:2155780, PubMed:23895467, PubMed:25445488, PubMed:26370147, PubMed:34473954). Plays a role in synaptic plasticity (By similarity). Contribut...

    Polypeptides: Glycine receptor subunit alpha-2
  10. Target

    Ephrin type-A receptor 2

    go.drugbank.com/bio_entities/BE0000841
    TargetHumans

    The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. … Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells.

    Polypeptides: Ephrin type-A receptor 2Synonyms: Tyrosine-protein kinase receptor ECK