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Displaying results 1 - 10 of 14 in total
  1. Pathway

    Chlorpromazine - Serotonin Antagonist Action Pathway

    smpdb.ca/view/SMP0126487
    Drug action

    to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1 … pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate

    Drugs: Pyridoxal phosphate · Tryptophan · Sapropterin · Chlorpromazine · Calcium · Iron +1 more
    Enzymes: Sodium-dependent serotonin transporter
  2. Pathway

    Acepromazine - Serotonin Antagonist Action Pathway

    smpdb.ca/view/SMP0126586
    Drug action

    gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors … - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia

    Drugs: Pyridoxal phosphate · Tryptophan · Sapropterin · Calcium · Iron · Acepromazine +1 more
    Enzymes: Sodium-dependent serotonin transporter
  3. Pathway

    Pipotiazine Serotonin antagonist Action Pathway

    smpdb.ca/view/SMP0126800
    Drug action

    gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors … - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia

    Drugs: Pyridoxal phosphate · Tryptophan · Sapropterin · Calcium · Iron · Pipotiazine +1 more
    Enzymes: Sodium-dependent serotonin transporter
  4. Drug

    Aripiprazole

    go.drugbank.com/drugs/DB01238
    ApprovedInvestigational

    [L45859] Aripiprazole exerts its effects through agonism of dopaminergic and 5-HT1A receptors and antagonism of alpha-adrenergic and 5-HT2A receptors. … Aripiprazole is an atypical antipsychotic orally indicated for the treatment of schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette's.

    Categories: Aripiprazole and prodrugs, Histamine AntagonistsProducts: ABILIFY MAINTENA POWDER AND SOLVENT FOR PROLONGED RELEASE SUSPENSION FOR INJECTION 400 MG, Abilify Maintena 400 mg powder and solvent for prolonged-release suspension for injection
  5. Drug

    Clozapine

    go.drugbank.com/drugs/DB00363
    ApprovedInvestigational

    [A185747] However, its promiscuity toward the muscarinic and adrenergic receptors can result in other side effects, notably gastrointestinal hypomotility and orthostatic hypotension. [L905,A215552]. … [A256708] Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical

    Categories: Diazepines, Oxazepines, Thiazepines and Oxepines, Histamine Antagonists
  6. Drug

    Desvenlafaxine

    go.drugbank.com/drugs/DB06700
    ApprovedInvestigational

    [A261271] Desvenlafaxine has a very similar pharmacological, efficacy, and safety profile as [venlafaxine]. … Like its parent drug, desvenlafaxine is also an antidepressant belonging to the class of serotonin-norepinephrine reuptake inhibitor (SNRI) class.

    Categories: Serotonin and Noradrenaline Reuptake Inhibitors, Serotonin Agents
  7. Drug

    Ziprasidone

    go.drugbank.com/drugs/DB00246
    ApprovedInvestigational

    Disorders such as schizophrenia and bipolar disorder can significantly impair mood, cognition, and behavior. … [A190525] These mental illnesses can often be accompanied by comorbidities such as depression and substance abuse, and can significantly impact the quality of life of patients and caregivers.

    Categories: Histamine Antagonists, Histamine H1 Antagonists
  8. Drug

    Zuclopenthixol

    go.drugbank.com/drugs/DB01624
    ApprovedInvestigational

    It is an antagonist at D1 and D2 dopamine receptors. Major brands of zuclopenthixol are Cisordinol, Acuphase, and Clopixol. This drug is a liquid. This compound belongs to the thioxanthenes. … Known drug targets of zuclopenthixol include 5-hydroxytryptamine receptor 2A, D(1B) dopamine receptor, D(2) dopamine receptor, D(1A) dopamine receptor, and alpha-1A adrenergic receptor.

    Categories: Histamine Antagonists, Histamine H1 Antagonists
  9. Drug

    Prochlorperazine

    go.drugbank.com/drugs/DB00433
    ApprovedInvestigationalVet approved

    [label] It mainly works by depressing the chemoreceptor trigger zone and blocking D2 dopamine receptors in the brain. It was shown to also block histaminergic, cholinergic and noradrenergic receptors. … Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation antipsychotic drug that is used for the treatment of severe nausea and vomiting, as well as short-term management

  10. Drug

    Tradipitant

    go.drugbank.com/drugs/DB12580
    ApprovedInvestigational

    [L54903] NK-1 receptors are expressed in the brainstem and nucleus tractus solitarius, which receives emetogenic signals from various stimuli including dizziness and vertigo. … [L54903] Tradipitant has also been investigated in gastroparesis,COVID-19-induced pneumonia, and atopic dermatitis.[A275348, A275358, A275363]