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Displaying results 1 - 10 of 2727 in total
  1. Pathway

    Calcium carbonate Drug Metabolism

    smpdb.ca/view/SMP0130489
    Metabolic

    Calcium carbonate passes through the liver and is then excreted from the body mainly through the kidney. … Calcium carbonate is a drug that is not metabolized by the human body as determined by current research and biotransformer analysis.

    Drugs: Calcium carbonate
  2. Pathway

    Verapamil Calcium Channel Vasodilation Action Pathway

    smpdb.ca/view/SMP0126373
    Drug action

    The inhibition of L-type calcium channels prevents the influx of calcium in vascular smooth muscle myocytes and the heart's cardiomyocytes, which prevents contraction of vascular smooth muscles and heart … Verapamil is an L-type calcium channel blocker with antiarrhythmic, antianginal, and antihypertensive activity.

    Drugs: ATP · Verapamil · Calcium · Magnesium cation
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent calcium channel subunit alpha-2/delta-1
  3. Pathway

    Diltiazem Calcium Channel Vasodilation Action Pathway

    smpdb.ca/view/SMP0126505
    Drug action

    This effect is thought to be mediated by the voltage-dependent block of the L-type calcium channels and inhibition of calcium ion release from the ER stores, without altering the sodium-calcium coupled … transport or calcium sensitivity of myofilaments.

    Drugs: ATP · Diltiazem · Calcium · Magnesium cation
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent calcium channel subunit alpha-2/delta-1
  4. Pathway

    Cinnarizine Calcium Channel Vasodilation Action Pathway

    smpdb.ca/view/SMP0126667
    Drug action

    Cinnarizine is an antihistamine and a calcium channel blocker. Cinnarizine inhibits contractions of vascular smooth muscle cells by blocking L-type and T-type voltage gated calcium channels. … Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain.

    Drugs: ATP · Cinnarizine · Calcium · Magnesium cation
    Enzymes: Voltage-dependent T-type calcium channel subunit alpha-1G, Voltage-dependent T-type calcium channel subunit alpha-1H
  5. Pathway

    Diltiazem Calcium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126292
    Drug action

    This effect is thought to be mediated by the voltage-dependent block of the L-type calcium channels and inhibition of calcium ion release from the ER stores, without altering the sodium-calcium coupled … transport or calcium sensitivity of myofilaments.

    Drugs: Diltiazem · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1G
  6. Pathway

    Flunarizine Calcium Channel Artery Dilation Action Pathway

    smpdb.ca/view/SMP0126303
    Drug action

    Flunarizine is a selective calcium entry blocker with calmodulin binding properties and histamine H1 blocking activity. … Flunarizine inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel.

    Drugs: ATP · Calcium · Magnesium cation · Flunarizine
    Enzymes: Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent calcium channel subunit alpha-2/delta-1
  7. Pathway

    Verapamil Calcium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126428
    Drug action

    This activity is dependent on calcium influx through L-type calcium channels. … Activation of L-type calcium channels allows the influx of calcium ions into the muscles upon depolarization and excitation of the channel.

    Drugs: Verapamil · Potassium cation · Calcium · Cyclic adenosine monophosphate
    Enzymes: Voltage-dependent P/Q-type calcium channel subunit alpha-1A, Voltage-dependent T-type calcium channel subunit alpha-1G
  8. Pathway

    Enflurane Calcium Channel Cardiac Muscle Relaxation Action Pathway

    smpdb.ca/view/SMP0126668
    Drug action

    My decreasing the amount of intracellular calcium available, calcium cannot readily bind to calmodulin and muscle contraction is inhibited. … Studies have found that enflurane binds to the calcium channels in the cardiac sarcoplasmic reticulum causing cardio depressant effects.

    Drugs: ATP · Enflurane · Epinephrine · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  9. Pathway

    Bevantolol Beta Blocker Cardiac Action Pathway

    smpdb.ca/view/SMP0122915
    Drug action

    Bevantolol is a beta blocker and calcium channel blocker. It is an oral drug used for the treatment of angina pectoris and hypertension. … Protein kinase is required to activate calcium channels in the cell membrane, causing them to open and allow Ca2+ to enter the cell.

    Drugs: ATP · Bevantolol · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G
  10. Pathway

    Arbutamine Action Pathway

    smpdb.ca/view/SMP0123258
    Drug action

    Protein kinase activates calcium channels in the membrane, causing them to open and allow Ca2+ to enter the cell. Due to this effect, there is high concentration of Ca2+ in the cell.

    Drugs: ATP · Arbutamine · Calcium
    Enzymes: Sodium/calcium exchanger 1, Voltage-dependent T-type calcium channel subunit alpha-1G